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| | 2,3',4'-TRICHLOROACETOPHENONE Basic information |
| Product Name: | 2,3',4'-TRICHLOROACETOPHENONE | | Synonyms: | 3,4-DICHLOROPHENACYL CHLORIDE;1-ETHANONE, 2-CHLORO-1-(3,4-DICHLOROPHENYL)-;2-CHLORO-1-(3,4-DICHLOROPHENYL)-1-ETHANONE;2-CHLORO-1-(3,4-DICHLORO-PHENYL)-ETHANONE;2-chloro-3-4-dichloroacetophenone;2-Chloro-1-(3,4-dichlorophenyl)ethan-1-one, 2,3',4'-Trichloroacetophenone;3,4-Dichlorophenacyl chloride 95%;2-Chloro-1-(3,4-dichlorophenyl) | | CAS: | 42981-08-8 | | MF: | C8H5Cl3O | | MW: | 223.48 | | EINECS: | | | Product Categories: | | | Mol File: | 42981-08-8.mol |  |
| | 2,3',4'-TRICHLOROACETOPHENONE Chemical Properties |
| Melting point | 46-47°C | | Boiling point | 171-173°C 15mm | | density | 1.430±0.06 g/cm3(Predicted) | | Fp | 171-173°C/15mm | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in methanol. | | form | powder to crystal | | color | White to Almost white | | CAS DataBase Reference | 42981-08-8(CAS DataBase Reference) |
| Risk Statements | 34 | | Safety Statements | 36/37/39 | | RIDADR | 1759 | | HazardClass | 8 | | PackingGroup | III | | HS Code | 2914390090 |
| Provider | Language |
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ALFA
| English |
| | 2,3',4'-TRICHLOROACETOPHENONE Usage And Synthesis |
| Uses | 2,3',4'-Trichloroacetophenone is used as an organic chemical synthesis intermediate. | | Synthesis | General method: 1,2-Dichlorobenzene (50 g, 340 mmol) was mixed with anhydrous AlCl3 (45.354 g, 340 mmol) and heated to 70 °C. The mixture was then heated to 70 °C. The reaction was followed by the addition of 3-chloropropionyl chloride (47.506 g, 374 mmol). Subsequently, 3-chloropropionyl chloride (47.506 g, 374 mmol) was added slowly and dropwise. The reaction mixture was stirred continuously at 70 °C for 6 hours. After the reaction was completed, it was cooled to room temperature and diluted with dichloromethane (300 mL). The diluted mixture was slowly poured into ice water (200 mL) and stirred for 30 minutes. The organic layer was separated, washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluent: EtOAc/hexane=1/50, V/V) to afford the target product 2,3',4'-trichloroacetophenone (compound 2a) as a white solid (64.6 g, 80% yield). | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 24, p. 5420 - 5423
[2] Quarterly Journal of Pharmacy and Pharmacology, 1932, vol. 5, p. 500
[3] Chem. Zentralbl., 1933, vol. 104, # I, p. 605
[4] Roczniki Chemii, 1933, vol. 13, p. 293,295
[5] Chem. Zentralbl., 1933, vol. 104, # II, p. 1516 |
| | 2,3',4'-TRICHLOROACETOPHENONE Preparation Products And Raw materials |
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