2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide

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2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide manufacturers

  • Retro-2
  • Retro-2 pictures
  • $64.00
  • 2026-07-15
  • CAS:1201652-50-7
  • Purity: 98.15%
  • Supply Ability: 10g
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide Basic information
Product Name:2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide
Synonyms:2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide;2-{[(E)-(5-methylthiophen-2-yl)methylidene]amino}-N-phenylbenzamide;Benzamide, 2-[(E)-[(5-methyl-2-thienyl)methylene]amino]-N-phenyl-;2-{[(5-methyl-2-thienyl)methylene]amino};(E)-2-(((5-Methylthiophen-2-yl)methylene)amino)-N-phenylbenzamide;LC3-II,inhibit,Inhibitor,Retro-2,retrograde,Shiga-like,Golgi,Filovirus,toxins,Retro2,GFP-LC3,trafficking,Autophagy,Parasite;Retro-2, 10 mM in DMSO
CAS:1201652-50-7
MF:C19H16N2OS
MW:320.41
EINECS:
Product Categories:
Mol File:1201652-50-7.mol
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide Structure
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide Chemical Properties
Boiling point 461.9±40.0 °C(Predicted)
density 1.17±0.1 g/cm3(Predicted)
pka13.20±0.70(Predicted)
form Solid
color White to yellow
Safety Information
MSDS Information
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide Usage And Synthesis
UsesRetro-2 is a selective inhibitor of retrograde protein trafficking at the endosome-trans-Golgi network interface. Retro-2 is an ebolavirus (EBOV) infection inhibitor with an EC50 of 12.2 μM in HeLa cells. Retro-2 induces cell autophagy[1][2][3].
in vivo

Retro-2 (2-200 mg/kg; i.p; daily; for 21 days) treatment clearly protects from lethal nasal exposure to ricin in mice. 200 mg/kg of Retro-2 fully protects mice against ricin challenge[1].

Animal Model:Female Balb/c mice (Pathogen-free 6-week-old) injected with ricin (2 μg/kg)[1]
Dosage:2 mg/kg, 10 mg/kg, 20 mg/kg, 200 mg/kg
Administration:Intraperitoneal injection; daily; for 21 days
Result:Protected mice against ricin challenge.
IC 50Leishmania; EBOV
References[1] Bahne Stechmann, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141(2):231-42. DOI:10.1016/j.cell.2010.01.043
[2] Valérie Nicolas, et al. Small Trafficking Inhibitor Retro-2 Disrupts the Microtubule-Dependent Trafficking of Autophagic Vacuoles. Front Cell Dev Biol. 2020 Jun 18;8:464. DOI:10.3389/fcell.2020.00464
[3] Olena Shtanko, et al. Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection. Antiviral Res. 2018 Jan;149:154-163. DOI:10.1016/j.antiviral.2017.11.016
2-{[(5-methyl-2-thienyl)methylene]amino}-N-phenylbenzamide Preparation Products And Raw materials
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