- Loganic acid
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- $50.00 / 1mL
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2026-05-11
- CAS:22255-40-9
- Min. Order:
- Purity: 99.17%
- Supply Ability: 10g
- Loganic acid
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- $0.00 / 20mg
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2023-02-24
- CAS:22255-40-9
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- LOGANIC ACID
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- $15.00 / 1KG
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2021-07-02
- CAS:22255-40-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | LOGANIC ACID Basic information |
| Product Name: | LOGANIC ACID | | Synonyms: | LOGANIC ACID;[1S-(1alpha,4aalpha,6alpha,7alpha,7aalpha)]-1-(beta-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid;(1S-(1alpha,4aalpha,6alpha,7alpha,7aalpha))-1-(beta-D-Glucopyranosylox y)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta(c)pyran-4-carb oxylic acid;LOGANIC ACID hplc;LOGANIC ACID WITH HPLC;(1S)-1α-(β-D-Glucopyranosyloxy)-6α-hydroxy-7α-methyl-1,4aα,5,6,7,7aα-hexahydrocyclopenta[c]pyran-4-carboxylic acid;[1S-(1a,4aa,6a,7a,7aa)]-1-(beta-D-Glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid;[1S-(1α,4aα,6α,7α,7aα)]-1-(β-D-glucopyranosyloxy)-1,4a,5,6,7,7a-hexahydro-6-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylic acid | | CAS: | 22255-40-9 | | MF: | C16H24O10 | | MW: | 376.36 | | EINECS: | 244-875-9 | | Product Categories: | chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Iridoids | | Mol File: | 22255-40-9.mol |  |
| | LOGANIC ACID Chemical Properties |
| Boiling point | 646.3±55.0 °C(Predicted) | | density | 1.60±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in methan | | form | powder | | pka | 4.55±0.70(Predicted) | | color | White-beige | | Major Application | metabolomics
vitamins, nutraceuticals, and natural products | | InChIKey | JNNGEAWILNVFFD-CDJYTOATSA-N | | SMILES | C[C@H]1[C@@H](O)C[C@H]2[C@@H]1[C@@H](OC=C2C(O)=O)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O | | LogP | -2.411 (est) |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | LOGANIC ACID Usage And Synthesis |
| Description | Loganic acid is an iridoid glycoside that has been found in C. mas and has diverse biological activities, including antidiabetic, antiadipogenic, anti-atherosclerotic, and anti-inflammatory properties. Loganic acid (1 μM) stimulates glucagon-like peptide-1 (GLP-1) secretion by NCI H716 human enteroendocrine colorectal cancer cells. It inhibits dexamethasone-, 3-isobutyl-1-methylxanthine-, and insulin-induced differentiation of mouse 3T3-L1 fibroblasts into adipocytes when used at a concentration of 10 μg/ml. Loganic acid (20 mg/kg per day) decreases the plasma atherogenic index, a ratio of triglyceride to HDL cholesterol, and the cardiac risk ratio, a ratio of total cholesterol to HDL cholesterol, in a rabbit model of atherosclerosis induced by a cholesterol-rich diet. It also decreases IL-6, TNF-α, and oxidized LDL (oxLDL) plasma levels in the same model. | | Chemical Properties | Off-white crystalline powder, soluble in methanol, derived from Gentiana macrophylla. | | Uses | Loganic Acid is found to be present in both the fermented fruits and brines. Exhibits antioxidant activity. | | Definition | ChEBI: A cyclopentapyran that is 1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid substituted at positions 1, 6 and 7 by beta-D-glucosyloxy, hydroxy and methyl groups respectively | | References | [1] CARMINE J. COSCIA Luigi B Rocco Guarnaccia. Monoterpene biosynthesis. I. Occurrence and mevalonoid origin of gentiopicroside and loganic acid in Swertia caroliniensis[J]. Biochemistry Biochemistry, 1969, 8 12: 5036-5043. DOI: 10.1021/bi00840a054
[2] HYO-WEON SUH . A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db/db mouse[J]. Journal of ethnopharmacology, 2015, 172: Pages 219-226. DOI: 10.1016/j.jep.2015.06.042
[3] EUNKUK PARK. Antiadipogenic Effects of Loganic Acid in 3T3-L1 Preadipocytes and Ovariectomized Mice.[J]. Molecules, 2018, 23 7. DOI: 10.3390/molecules23071663
[4] TOMASZ SOZASKI . Iridoid–loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation[J]. Atherosclerosis, 2016, 254: Pages 151-160. DOI: 10.1016/j.atherosclerosis.2016.10.001 |
| | LOGANIC ACID Preparation Products And Raw materials |
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