| Company Name: |
BOC Sciences |
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1-631-485-4226; 16314854226 |
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MRS 1706 manufacturers
- MRS-1706
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- $72.00
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2026-07-14
- CAS:264622-53-9
- Purity: 99.00%
- Supply Ability: 10g
- MRS 1706
-
-
2026-06-30
- CAS:264622-53-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
- MRS-1706
-
-
2026-06-30
- CAS:264622-53-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1000kg
|
| | MRS 1706 Basic information |
| Product Name: | MRS 1706 | | Synonyms: | MRS-1706;MRS 1706;MRS1706;N-(4-ACETYLPHENYL)-2-[4-(2,3,6,7-TETRAHYDRO-2,6-DIOXO-1,3-DIPROPYL-1H-PURIN-8-YL)PHENOXY]ACETAMIDE;MRS 1706;N-(4-acetylphenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide;Acetamide, N-(4-acetylphenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-;N-(4-Acetylphenyl)-2-(4-(2,6-dioxo-1,3-dipropyl-2,3,6,9-tetrahydro-1H-purin-8-yl)phenoxy)acetamide;MRS-1706,cAMP,P1 receptor,corpus cavernosal strips,duration,inhibit,MRS 1706,Adenosine Receptor,MRS1706,Inhibitor,adenosine,magnitude;MRS-1706, 10 mM in DMSO | | CAS: | 264622-53-9 | | MF: | C27H29N5O5 | | MW: | 503.55 | | EINECS: | | | Product Categories: | | | Mol File: | 264622-53-9.mol |  |
| | MRS 1706 Chemical Properties |
| density | 1.293±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO : 6.4 mg/mL (12.71 mM; Need ultrasonic and warming)H2O : < 0.1 mg/mL (insoluble) | | form | Powder | | pka | 8.25±0.70(Predicted) | | color | Off-white to yellow | | InChIKey | ZKUCFFYOQOJLGT-UHFFFAOYSA-N | | SMILES | O=C(COC1=CC=C(C=C1)C2=NC3=C(N2)N(C(N(C3=O)CCC)=O)CCC)NC4=CC=C(C=C4)C(C)=O |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | MRS 1706 Usage And Synthesis |
| Description | MRS1706 is a selective adenosine A2B receptor inverse agonist with Ki values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively. | | Uses | MRS 1706 is a selective and potent Adenosine A2B-R inverse agonist Ki (binding affinity) values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively. | | Biological Activity | Potent and selective adenosine A 2B receptor inverse agonist (K i values are 1.39, 157, 112 and 230 nM for human A 2B , A 1 , A 2A and A 3 receptors respectively). | | in vivo | MRS-1706 (1-10 μM; intracavernous injection; Ada–/– mice) reduces the magnitude and duration of electrical field stimulation (EFS)-induced contraction of corpus cavernosal strips (CCSs) from sickle cell disease (SCD) transgenic mice and inhibits the level of cAMP[2]. | Animal Model: | Ada–/– mice[2] | | Dosage: | 1 and 10 μM | | Administration: | Intracavernous injection | | Result: | Inhibited A2BR signaling and reduced the magnitude and duration.
Inhibited the level of cAMP.
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| | References | [1] YONG-CHUL KIM. Anilide Derivatives of an 8-Phenylxanthine Carboxylic Congener Are Highly Potent and Selective Antagonists at Human A2B Adenosine Receptors[J]. Journal of Medicinal Chemistry, 2000, 43 6: 1165-1172. DOI: 10.1021/jm990421v
[2] QILAN LI. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 2007, 320 2: 637-645. DOI: 10.1124/jpet.106.111203 |
| | MRS 1706 Preparation Products And Raw materials |
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