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| | 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol Basic information | | Uses |
| | 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol Chemical Properties |
| Melting point | 246-250 °C (lit.) | | density | 1.63±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Methanol | | form | Powder | | pka | 6.21±0.20(Predicted) | | color | White to Almost white | | λmax | 270nm(MeOH)(lit.) | | InChI | 1S/C5H3F3N2OS/c6-5(7,8)2-1-3(11)10-4(12)9-2/h1H,(H2,9,10,11,12) | | InChIKey | YZAOETRYQWFEOY-UHFFFAOYSA-N | | SMILES | Oc1cc(nc(S)n1)C(F)(F)F | | CAS DataBase Reference | 368-54-7(CAS DataBase Reference) | | NIST Chemistry Reference | Uracil, 2-thio-6-(trifluoromethyl)-(368-54-7) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29335990 | | Storage Class | 11 - Combustible Solids |
| | 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol Usage And Synthesis |
| Uses | 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol is a pyrimidine derivative that can be used to prepare drugs for cancer treatment, antibacterial activity, antimalarial treatment, and arthritis treatment; it can also be used in the synthesis of herbicides, insecticides, and fungicides. For example, the antimalarial drug pyrimethamine, the antihypertensive drug minoxidil, the anticancer drug 5-fluorouracil, and the pesticide fungicides ethirimol and methylpyrimethanil all contain pyrimidine structures. | | Uses | 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol (HTPT) can form a stable monolayer on the Au(111) surface. | | General Description | 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol (HTPT) can form a stable monolayer on the Au(111) surface. | | Synthesis | A 250mL three-necked flask equipped with mechanical stirring and a reflux condenser tube was charged with 27.6g (0.15 mol) ethyl trifluoroacetoacetate, 11.4g (0.15 mol) thiourea,100 mLDMF, heated to 120C, and the reaction was carried out for 4 hours. Cooling, decompression recovery of solvent, cooling precipitation of crystals, filtration, washed with water, the product 4-hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol 25.3g (yield: 86.0%). |
| | 4-Hydroxy-6-(trifluoromethyl)pyrimidine-2-thiol Preparation Products And Raw materials |
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