| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
|
| Product Name: | REC IL-1RA (HUMAN) | | Synonyms: | Mouse Interleukin 1 receptor antagonist elisa kit;IL-1RA, HUMAN;INTERLEUKIN 1 RECEPTOR ANTAGONIST;HUMAN IL-1RA;REC INTERLEUKIN-1 RECEPTOR ANTAGONIST (HUMAN);REC IL-1RA (HUMAN);Mini Sample Mouse IL-1ra/IL-1F3;IL-1RA, ICIL-1RA, IRAP, IL-1RN | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![REC IL-1RA (HUMAN) Structure]() |
| | REC IL-1RA (HUMAN) Chemical Properties |
| storage temp. | -15°C | | form | lyophilized | | color | white to off-white | | biological source | human |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | REC IL-1RA (HUMAN) Usage And Synthesis |
| Uses | IL-1Ra human has been used as an IL1 antagonist to block the signaling from the IL1 receptor and verify th at IL1 signaling is responsible for invasiveness in CD133-expressing cells. It has also been used as a control in sandwich enzyme-linked immunosorbent assay (ELISA) to measure protein levels. | | General Description | The gene IL-1RA (interleukin-1 receptor antagonist) is mapped to human chromosome 2q. It belongs to the IL-1 (interleukin 1) family of proteins. The encoded protein has a TIR (Toll/IL-1 receptor) domain. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages and fibroblasts. It is a naturally occurring inflammatory inhibitor protein. Recombinant human IL-1RA is a 17.2kDa protein consisting of 153 amino acid residues. | | Biochem/physiol Actions | Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α (interleukin 1 α) and IL-1β (interleukin 1 β) by competitively blocking binding to their type I and type II receptors. Therapeutically, IL-1RA may help in the treatment of sepsis, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Low production of IL-1RA is observed in HIV-1 (human immunodeficiency virus 1)-infected dendritic cells. | | Description | IL1ra Human Recombinant produced in E.Coli is a non-glycosylated, N-terminal methionyl form of the human naturally-occurring polypeptide chain containing 153 amino acids and having a molecular mass of 17000 Dalton.
The IL1ra is purified by proprietary chromatographic techniques. | | Source | Escherichia Coli | | Background | Interleukin-1 ra is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| | REC IL-1RA (HUMAN) Preparation Products And Raw materials |
|