| Company Name: |
Sigma-Aldrich |
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Company Name: |
amyjet |
| Tel: |
4006800868;027-59626688 18771149750 |
| Email: |
sales@amyjet.com |
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| Product Name: | C-REACTIVE PROTEIN, HUMAN | | Synonyms: | RHCRP;CRP, HUMAN;CRP HUMAN SERUM;C-REACTIVE PROTEIN, HUMAN;C-REACTIVE PROTEIN, HUMAN ASCITES;C-REACTIVE PROTEIN, HUMAN, RECOMBINANT;C-REACTIVE PROTEIN HUMAN SERUM;C Reactive Protein from human fluids | | CAS: | 9007-41-4 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | proteins | | Mol File: | Mol File | ![C-REACTIVE PROTEIN, HUMAN Structure]() |
| | C-REACTIVE PROTEIN, HUMAN Chemical Properties |
| Boiling point | ~100 °C | | storage temp. | 2-8°C | | solubility | aqueous buffer: soluble | | form | buffered aqueous solution | | biological source | rabbit | | Water Solubility | water: soluble | | Major Application | cell analysis |
| Hazard Codes | Xn,B | | Risk Statements | 20/21/22-32-21/22-22 | | Safety Statements | 36/37-7 | | RIDADR | UN 3264 8 / PGIII | | WGK Germany | - | | HS Code | 3504009000 | | Storage Class | 10 - Combustible liquids |
| | C-REACTIVE PROTEIN, HUMAN Usage And Synthesis |
| Uses | For immunological applications in the preparation of antisera | | Uses | Human C-Reactive Protein ELISA Kit has been used to measure C-reactive protein (CRP) levels in serum. | | General Description | Recombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. | | Biochem/physiol Actions | C-reactive protein (CRP) plays a key role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release, and the production of interleukin-6 and tumor necrosis factor-α. It participates in the uptake of low-density lipoprotein in macrophages. CRP levels are elevated in people suffering from appendicitis, cholecystitis, pancreatitis, and meningitis. It plays a vital role in the pathophysiology of cardiovascular disease. Hence it is used as a marker of infection and cardiovascular events. | | Description | Human CRP produced in Human plasma having a molecular mass of 114 kDa.
It can be used as a marker for inflammation and also used for monitoring and prediction of future events in coronary artery disease. | | Source | Human Plasma | | Background | CRP is an acute phase protein that correlates with inflammatory disease and is synthesized by hepatocytes during the acute phase response by certain cytokines (IL-1 and TNF Alpha and Beta). CRP levels increase dramatically ( up to 1,000 fold) and serve as a useful marker of inflammation in such conditions as bacterial infection, rheumatoid arthritis, viral infections, transplantation rejection, meningitis, myocardial infarction, septicemia, osteomyelitis and others. CRP is also highly correlated to Serum Amyloid A levels. |
| | C-REACTIVE PROTEIN, HUMAN Preparation Products And Raw materials |
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