|
|
| | N1-CYCLOPROPYL-2-CHLOROACETAMIDE Basic information |
| Product Name: | N1-CYCLOPROPYL-2-CHLOROACETAMIDE | | Synonyms: | OTAVA-BB BB7020410100;N1-CYCLOPROPYL-2-CHLOROACETAMIDE;AKOS USSH-4110472;AKOS BBS-00006513;2-CHLORO-N-CYCLOPROPYLACETAMIDE;[N-(cyclopropyl)aminocarbonylmethyl]chloride;2-chloro-N-cyclopropylacetamide(SALTDATA: FREE);Acetamide, 2-chloro-N-cyclopropyl- | | CAS: | 19047-31-5 | | MF: | C5H8ClNO | | MW: | 133.58 | | EINECS: | | | Product Categories: | Amines;Ring Systems | | Mol File: | 19047-31-5.mol |  |
| | N1-CYCLOPROPYL-2-CHLOROACETAMIDE Chemical Properties |
| Melting point | 81-84 | | Boiling point | 295.8±19.0 °C(Predicted) | | density | 1.21±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | pka | 14.08±0.20(Predicted) | | Appearance | White to light brown Solid |
| Hazard Codes | Xi | | Hazard Note | Harmful | | HazardClass | IRRITANT | | HS Code | 2924190090 |
| | N1-CYCLOPROPYL-2-CHLOROACETAMIDE Usage And Synthesis |
| Synthesis | To a solution of cyclopropylamine (50.0 g, 0.876 mol) in dichloromethane (700 mL) was added 2-chloroacetyl chloride (49.4 g, 0.436 mol) slowly and dropwise through an addition funnel at 0 °C. The reaction mixture was stirred continuously at 0 °C for 2 h, followed by filtration through a diatomaceous earth pad. The filtrate was concentrated under reduced pressure to give an orange solid. The solid was slurried in 500 mL of hexane and filtered again. The collected orange solid was dried under vacuum at room temperature for 30 min to give the final 2-chloro-N-cyclopropylacetamide (58.12 g, 99% yield). Mass spectrometry analysis (m/z): 134.1 (M++1). | | References | [1] Patent: WO2006/47124, 2006, A1. Location in patent: Page/Page column 11-12
[2] Journal of Medicinal Chemistry, 2003, vol. 46, # 3, p. 399 - 408
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 6, p. 678 - 681
[4] Patent: CN106146414, 2016, A. Location in patent: Paragraph 0478; 0479; 0480
[5] ChemMedChem, 2018, |
| | N1-CYCLOPROPYL-2-CHLOROACETAMIDE Preparation Products And Raw materials |
|