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| | 2-Chloro-5-fluoroaniline Basic information |
| | 2-Chloro-5-fluoroaniline Chemical Properties |
| Melting point | 26°C | | Boiling point | 211°C | | density | 1.349±0.06 g/cm3(Predicted) | | refractive index | 1.5560 | | Fp | 211°C | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | clear liquid | | pka | 1+-.0.10(Predicted) | | color | Colorless to Light yellow to Light orange | | Water Solubility | Insoluble in water. | | FreezingPoint | 17.0 to 22.0 ℃ | | InChI | InChI=1S/C6H5ClFN/c7-5-2-1-4(8)3-6(5)9/h1-3H,9H2 | | InChIKey | VWUFOZAFKYOZJB-UHFFFAOYSA-N | | SMILES | C1(N)=CC(F)=CC=C1Cl | | CAS DataBase Reference | 452-83-5(CAS DataBase Reference) |
| | 2-Chloro-5-fluoroaniline Usage And Synthesis |
| Chemical Properties | Yellowish oily liquid or crystal | | Uses | 2-Chloro-5-fluoroaniline is used as a pharmaceutical intermediate. | | Synthesis | The general procedure for the synthesis of 2-chloro-5-fluoroaniline from 2-chloro-5-fluoronitrobenzene was as follows: a mixture of 0.17 g (1 mmol) of 2-chloro-5-fluoronitrobenzene, 1.13 g (5 mmol) of tin(II) chloride dihydrate, and 10 mL of ethanol was stirred for 0.5 hours at 70 °C. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently poured into 30 mL of water, alkalized with 10% sodium carbonate solution and extracted with dichloromethane. The organic layer was dried over anhydrous sodium sulfate and evaporated to dryness to give 0.12 g (84.5% yield) of the target product 2-chloro-5-fluoroaniline. The structure of the product was confirmed by 1H-NMR (CDCl3, δ): 4.16 (single peak, 2H, NH2), 6.51-6.77 (multiple peaks, 2H, CH on the benzene ring), 7.09-7.21 (multiple peaks, 1H, CH on the benzene ring). | | References | [1] Patent: EP1200406, 2004, B1. Location in patent: Page 14
[2] Green Chemistry, 2012, vol. 14, # 11, p. 3164 - 3174,11 |
| | 2-Chloro-5-fluoroaniline Preparation Products And Raw materials |
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