1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE manufacturers
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| | 1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE Basic information |
| Product Name: | 1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE | | Synonyms: | 1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE;1-Benzylhexahydropyrrolo[3,4-b]pyrrole;octahydro-1-(phenylmethyl)-Pyrrolo[3,4-b]pyrrole;1-benzyl-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[2,3-c]pyrrole;1-(phenylmethyl)-3,3a,4,5,6,6a-hexahydro-2H-pyrrolo[2,3-c]pyrrole;Pyrrolo[3,4-b]pyrrole, octahydro-1-(phenylmethyl)- | | CAS: | 132414-50-7 | | MF: | C13H18N2 | | MW: | 202.3 | | EINECS: | | | Product Categories: | Heterocycles series | | Mol File: | 132414-50-7.mol | ![1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE Structure](CAS/GIF/132414-50-7.gif) |
| | 1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE Chemical Properties |
| Boiling point | 304.4±17.0 °C(Predicted) | | density | 1.074±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 10.80±0.20(Predicted) |
| | 1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE Usage And Synthesis |
| Uses | 1-Benzyloctahydropyrrolo[3,4-b]pyrrole is used in the synthesis of intermediates as quinolone anti-bacterials. | | Synthesis | General procedure for the synthesis of 1-benzyl octahydropyrrolo[3,4-B]pyrrole-5(1H)-carboxylic acid from ethyl 1-benzylhexahydropyrrolo[3,4-B]pyrrole: Ethyl 1-benzyl octahydropyrrolo[2,3-c]pyrrole-5-carboxylate (2.1 g, 7.65 mmol) was dissolved in 37% hydrochloric acid (11 mL), and the reaction was heated and refluxed for 24 hours. Upon completion of the reaction, the pH of the reaction solution was adjusted to 8 with sodium carbonate, followed by multiple extractions of the product with dichloromethane. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford 1.4 g of 1-benzyl octahydropyrrolo[3,4-B]pyrrole (90% yield) as a brown oil, which could be used for the next reaction without further purification. Mass spectral analysis (m/z): 203.2 [MH]+. | | References | [1] Patent: WO2017/21920, 2017, A1. Location in patent: Paragraph 0633; 0634
[2] Patent: US5071999, 1991, A |
| | 1-BENZYL-OCTAHYDRO-PYRROLO[3,4-B]PYRROLE Preparation Products And Raw materials |
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