H-151
| 中文名称 | H-151 |
|---|---|
| 中文同义词 | 1-(4-乙基苯基)-3-(1H-吲哚-3-基)脲;化合物H-151;H 151,STING拮抗剂;1-(4-乙基苯基)-3-(3-吲哚基)脲;STING拮抗剂(H-151);化合物H-151,10 MM DMSO 溶液;H-151试剂;H-151 10mM*1ml in DMSO |
| 英文名称 | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea |
| 英文同义词 | 1-(4-ethylphenyl)-3-(1H-indol-3-yl)urea;H151;H-151;H-151;H-151;STING ANTAGONIST;STING antagonist;N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea;H 151 NEW;Urea, N-(4-ethylphenyl)-N'-1H-indol-3-yl-;STING inhibitor;H 151 (H-151) |
| CAS号 | 941987-60-6 |
| 分子式 | C17H17N3O |
| 分子量 | 279.34 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 941987-60-6.mol |
| 结构式 |  |
H-151 性质
| 沸点 | 399.9±25.0 °C(Predicted) |
|---|---|
| 密度 | 1.298±0.06 g/cm3(Predicted) |
| 储存条件 | Sealed in dry,Room Temperature |
| 溶解度 | 溶于 DMSO (25 mg/ml) |
| 酸度系数(pKa) | 14.96±0.70(Predicted) |
| 形态 | 固体 |
| 颜色 | 米白色 |
| 稳定性 | 可在-20°C下的DMSO中的溶液储存长达3个月。 |
| InChI | InChI=1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21) |
| InChIKey | UJZDIKVQFMCLBE-UHFFFAOYSA-N |
| SMILES | N(C1=CC=C(CC)C=C1)C(NC1C2=C(NC=1)C=CC=C2)=O |
H-151是STING的共价拮抗剂，在人细胞和体内均具有显著的抑制活性。
| Target | Value |
|
STING
() |
H-151 (0.02-2 μM) reduces IFNβ luciferase reporter measurements of HEK293T cells.
H-151 (0.5 μM; 2 h) inhibits the phosphorylation of TBK1 in THP-1 cells.
H-151 (1 μM; 3 h) suppresses hsSTING palmitoylation.
H-151 (750 nmol per mouse; a single i.p.) markedly reduces systemic cytokine responses in CMA-treated mice.
H-151 (750 nmol per mouse; i.p. daily for 7 d) exhibits notable efficacy in
Trex1
−/−
mice that expressed a bioluminescent IFNβ reporter.
H-151 (750 nmol per mouse; i.p.) reaches effective systemic levels, displays a short half-life in the serum and forms an adduct to mmSTING in wild-type mice.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存储类别 | 11 - 可燃固体 |
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/07/06 | S6652 | H-151 | 941987-60-6 | 10mM (1mL in DMSO) | 958.23元 |
| 2026/07/06 | S6652 | H-151 H-151 | 941987-60-6 | 5mg | 970元 |