| Company Name: |
InvivoChem Gold |
| Tel: |
13549236410 |
| Email: |
sales@invivochem.cn |
BMS-8 manufacturers
- BMS-8
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- $33.00
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2026-07-15
- CAS:1675201-90-7
- Purity: 99.06%
- Supply Ability: 10g
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| Product Name: | BMS-8 | | Synonyms: | BMS-8;2-Piperidinecarboxylic acid, 1-[[3-bromo-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-;1-(3-bromo-4-((2-methylbiphenyl-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;PPI,BMS 8,BMS8,inhibit,BMS-8,Inhibitor,PD-L1,PD-1;1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid;BMS-8, 10 mM in DMSO;1-(3-Bromo-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid , BMS-8 | | CAS: | 1675201-90-7 | | MF: | C27H28BrNO3 | | MW: | 494.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1675201-90-7.mol |  |
| | BMS-8 Chemical Properties |
| Boiling point | 616.9±55.0 °C(Predicted) | | density | 1.334±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Methanol: slightly soluble | | form | A crystalline solid | | pka | 2.35±0.20(Predicted) | | color | White to off-white | | InChIKey | QRXBPPWUGITQLE-UHFFFAOYSA-N | | SMILES | N1(CC2=CC=C(OCC3C=CC=C(C4=CC=CC=C4)C=3C)C(Br)=C2)CCCCC1C(O)=O |
| | BMS-8 Usage And Synthesis |
| Description | BMS-8 is a small molecule inhibitor of the protein-protein interaction between programmed death protein 1 (PD-1) and its ligand programmed cell death ligand 1 (PD-L1) with an IC50 value of 146 nM in a homogeneous time-resolved fluorescence (HTRF) binding assay. | | Uses | BMS-8 is inhibitor of the PD-1/PD-L1 interaction by inducing PD-L1 dimerization through PD-1 interacting surface, binding at a hydrophobic cavity formed upon PD-L1 dimerization. | | References | [1] KATARZYNA GUZIK. Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1[J]. Journal of Medicinal Chemistry, 2017, 60 13: 5857-5867. DOI: 10.1021/acs.jmedchem.7b00293 |
| | BMS-8 Preparation Products And Raw materials |
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