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| | 5-PHENYLTHIO-1,2-DIAMINOBENZENE Basic information |
| Product Name: | 5-PHENYLTHIO-1,2-DIAMINOBENZENE | | Synonyms: | 5-PHENYLTHIO-1,2-DIAMINOBENZENE;3,4-DIAMINODIPHENYLSULFIDE;4-Phenylsulfenyl-o-phenylenediamine;4-Thiophenoxy-1,2-phenylenediamine;4-(Phenylthio)-1,2-benzenediamine;4-(Phenylthio)-o-phenylenediamine;4-PHENYLSULFANYLBENZENE-1,2-DIAMINE;1,2-diamino-4-phenylthiobenzene | | CAS: | 43156-48-5 | | MF: | C12H12N2S | | MW: | 216.3 | | EINECS: | 256-122-1 | | Product Categories: | Benzene derivates | | Mol File: | 43156-48-5.mol |  |
| | 5-PHENYLTHIO-1,2-DIAMINOBENZENE Chemical Properties |
| Melting point | >58°C (dec.) | | Boiling point | 441.5±35.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C(protect from light) | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 3.36±0.10(Predicted) | | color | Pale Purple to Purple | | Stability: | Air Sensitive | | CAS DataBase Reference | 43156-48-5(CAS DataBase Reference) |
| | 5-PHENYLTHIO-1,2-DIAMINOBENZENE Usage And Synthesis |
| Uses | 4-(Phenylthio)-1,2-benzenediamine is used in the synthesis of bis(2-chloroethyl)aminophosphoryl-containing compounds which are potential anticancer agents. It is also used in the synthesis of 2-substituted-2,3-dihyrdro-5-thiophenoxy-1H-1,3,2-benzodiazaphosphole 2-oxides which exhibit antimicrobial activity. | | Synthesis | General procedure for the synthesis of 4-(phenylthio)benzene-1,2-diamine from 2-nitro-5-phenylmercaptoaniline: 2-nitro-5-phenylmercaptoaniline (36.9 g) and 4 times its weight of ethanol, followed by 0.1 times the weight of platinum-carbon catalyst for 2-nitro-5-phenylmercaptoaniline, were added to a 500 mL four-necked flask equipped with thermometer and stirring device. The hydrogenation reaction was initiated with stirring and heated to 70-90°C under hydrogen atmosphere while pressurized to 1.0-2.0 MPa for 8 hours. Upon completion of the reaction, the platinum carbon catalyst was removed by filtration, followed by evaporation to remove ethanol to afford 4-(phenylthio)benzene-1,2-diamine (21.2 g), which can be used directly in the next step of the reaction. | | References | [1] Archiv der Pharmazie, 1983, vol. 316, # 7, p. 638 - 638
[2] Journal of Heterocyclic Chemistry, 2004, vol. 41, # 2, p. 273 - 276
[3] Patent: CN103242238, 2016, B. Location in patent: Paragraph 0039; 0040 |
| | 5-PHENYLTHIO-1,2-DIAMINOBENZENE Preparation Products And Raw materials |
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