1207629-49-9 (free)

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Company Name: TargetMol Chemicals Inc.  
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Email: marketing@targetmol.cn
Company Name: Shanghai Anbida Biotechnology Co., Ltd.  
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Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

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1207629-49-9 (free) Basic information
Product Name:1207629-49-9 (free)
Synonyms:GSK-2245035 1325212-97-2;GSK-2245035 maleate
CAS:1325212-97-2
MF:C24H38N6O6
MW:506.6
EINECS:
Product Categories:
Mol File:1325212-97-2.mol
1207629-49-9 (free) Structure
1207629-49-9 (free) Chemical Properties
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1207629-49-9 (free) Usage And Synthesis
UsesGSK2245035 maleate is a highly potent and selective intranasal Toll-Like receptor 7 (TLR7) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 maleate has pEC50s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 maleate effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 maleate is used for asthma[1].
References[1] Biggadike K, et al. Discovery of 6-Amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one (GSK2245035), a Highly Potent and Selective Intranasal Toll-Like Receptor 7 Agonist for the Treatment of Asthma. J Med Chem. 2016 Mar 10;59(5):1711-26. DOI:10.1021/acs.jmedchem.5b01647
1207629-49-9 (free) Preparation Products And Raw materials
Tag:1207629-49-9 (free)(1325212-97-2) Related Product Information
GSK2245035 8H-Purin-8-one, 6-amino-2-butoxy-7,9-dihydro-9-(phenylmethyl)- 1207629-49-9 (free) Butanoic acid, 4-[[[4-[[6-amino-7,8-dihydro-2-(2-methoxyethoxy)-8-oxo-9H-purin-9-yl]methyl]phenyl]methyl]amino]-4-oxo- Infliximab Lipopolysaccharides, from E. coli O55:B5