TAK-041 manufacturers
- TAK-041
-
- $31.00
-
2026-07-14
- CAS:1929519-13-0
- Purity: 99.95%
- Supply Ability: 10g
|
| | TAK-041 Basic information |
| Product Name: | TAK-041 | | Synonyms: | TAK-041;NBI-1065846;TAK-041 (Synonyms: NBI-1065846);(S)-2-(4-Oxobenzo[d][1,2,3]triazin-3(4H)-yl)-N-(1-(4-(trifluoromethoxy)phenyl)ethyl)acetamide;inhibit,deficits,social,BALB/c,NBI 1065846,NBI1065846,negative,schizophrenia,TAK-041,GPR139,symptoms,interaction,G Protein-Coupled Receptor 139,TAK 041,mouse,TAK041,Inhibitor;1,2,3-Benzotriazine-3(4H)-acetamide, 4-oxo-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]-;2-(4-oxo-3,4-dihydro-1,2,3-benzotriazin-3-yl)-N-[(1S)-1-[4-(trifluoromethoxy)phenyl]ethyl]acetamide;TAK-041, 10 mM in DMSO | | CAS: | 1929519-13-0 | | MF: | C18H15F3N4O3 | | MW: | 392.33 | | EINECS: | | | Product Categories: | | | Mol File: | 1929519-13-0.mol |  |
| | TAK-041 Chemical Properties |
| density | 1.42±0.1 g/cm3(Predicted) | | solubility | DMF: 3 mg/ml; DMSO: 1 mg/ml; Ethanol: insol; PBS (pH 7.2): insol | | form | A crystalline solid | | pka | 13.89±0.46(Predicted) | | color | White to off-white |
| | TAK-041 Usage And Synthesis |
| Uses | Zelatriazin (TAK-041; NBI-1065846) is a potent and selective GPR139 agonist with an EC50 of 22 nM. Zelatriazin has the potential for the research of negative symptoms associated with schizophrenia[1]. | | in vivo | Zelatriazin (0.03-3 mg/kg; P.o.) improves social behavior in BALB/c mice[1]. | Animal Model: | BALB/c mice[1] | | Dosage: | 0.03, 0.3, and 3 mg/kg | | Administration: | P.o. | | Result: | Dose-dependently improved the social behavior of BALB/c mice.
|
| | References | [1] Reichard HA, et al. Discovery of TAK-041: a Potent and Selective GPR139 Agonist Explored for the Treatment of Negative Symptoms Associated with Schizophrenia [published online ahead of print, 2021 Jul 14]. J Med Chem. 2021;10.1021/acs.jmedchem.1c00820. DOI:10.1021/acs.jmedchem.1c00820 |
| | TAK-041 Preparation Products And Raw materials |
|