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| | Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 Basic information |
| Product Name: | Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 | | Synonyms: | thr(4)-gly(7)-oxytoci;[THR4, GLY7] OT;[THR4, GLY7]-OXYTOCIN;H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2;H-CYS-TYR-ILE-THR-ASN-CYS-GLY-LEU-GLY-NH2, (DISULFIDE BOND);3,3-DiallylthiacarbocyanineBromide;Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 (Disulfide bridge Cys1-Cys6);TGOT | | CAS: | 60786-59-6 | | MF: | C39H61N11O12S2 | | MW: | 940.1 | | EINECS: | | | Product Categories: | | | Mol File: | 60786-59-6.mol |  |
| | Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 Chemical Properties |
| Boiling point | 1489.4±65.0 °C(Predicted) | | density | 1.265±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | form | Solid | | pka | 9.90±0.15(Predicted) | | color | White to off-white |
| Hazard Codes | Xn | | Risk Statements | 20 | | Safety Statements | 36/37/39-45 | | WGK Germany | 3 |
| | Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 Usage And Synthesis |
| Uses | (Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K+ channels. [1][2]. | | in vivo | (Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice[1].
(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats[3].
| Animal Model: | Swiss Webster mice [1] | | Dosage: | 1 μM | | Administration: | Intratracheal administration for 24 h | | Result: | Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons.
Increased the firing rate of TGOT-responsive PVT neurons in all subregions.
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| | References | [1] Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. DOI:10.1038/s41386-021-00961-3
[2] Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. DOI:10.1093/cercor/bhaa363
[3] M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11. DOI:10.1016/s0167-0115(97)00002-5 |
| | Cys-Tyr-Ile-Thr-Asn-Cys-Gly-Leu-Gly-NH2 Preparation Products And Raw materials |
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