AP521

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Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Email: liming@bio-fount.com
Company Name: BOC Sciences  
Tel: 16314854226; +8616314854226
Email: inquiry@bocsci.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: cjbscvictory  
Tel: 13348960310 13348960310
Email: 3003867561@qq.com
Company Name: TargetMol Chemicals Inc.  
Tel: 4008200310 15002144251
Email: marketing@tsbiochem.com

AP521 manufacturers

  • AP521
  • AP521 pictures
  • $1520.00
  • 2026-07-16
  • CAS:151227-08-6
  • Purity:
  • Supply Ability: 10g
  • AP521
  • AP521 pictures
  • $1520.00
  • 2026-07-15
  • CAS:151227-08-6
  • Purity:
  • Supply Ability: 10g
  • AP521
  • AP521 pictures
  • $1520.00
  • 2025-08-22
  • CAS:151227-08-6
  • Purity:
  • Supply Ability: 10g
AP521 Basic information
Product Name:AP521
Synonyms:AP521;AP521,AP-521;N-(1,3-Benzodioxol-5-ylmethyl)-1,2,3,4-tetrahydro-[1]benzothiolo[2,3-c]pyridine-3-carboxamide hydrochloride
CAS:151227-08-6
MF:C20H19ClN2O3S
MW:402.89
EINECS:
Product Categories:
Mol File:151227-08-6.mol
AP521 Structure
AP521 Chemical Properties
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color White to off-white
Safety Information
MSDS Information
AP521 Usage And Synthesis
UsesAP521 is an agonist of human 5-HT1A receptor with an IC50 of 94 nM.
in vivo

AP521 significantly increases the number of shock acceptances [F(5,105)=4.46, P<0.01] at doses between 0.5 to 10 mg/kg. Oral administration of AP521 at 3 and 10 mg/kg significantly decreases freezing time [F(3,60)=2.89, P<0.05]. AP521 significantly increases the time spent on the open arms by approximately 2-fold as compare to the vehicle treated group [F(3, 36)=4.21, P<0.05 for AP521]. The anxiolytic-like effect of AP521 appears to be dose-related. AP521 significantly increases the extracellular 5-HT level of the medial prefrontal cortex (mPFC) at 10 mg/kg from 0.5 to 1 h after administration. AP521 at 3 mg/kg tends to increase the extracellular 5-HT level, however, this increase is not significant[1].

IC 505-HT1A Receptor: 94 nM (IC50, in human); 5-HT1A Receptor: 135 nM (IC50, in rat); 5-HT1B Receptor: 254 nM (IC50, in rat); 5-HT1B Receptor: 5530 nM (IC50, in human); 5-HT1D Receptor: 418 nM (IC50, in human); 5-HT5A Receptor: 422 nM (IC50, in human); 5-HT7 Receptor: 198 nM (IC50, in rat)
References[1] Kasahara K, et al. The effects of AP521, a novel anxiolytic drug, in three anxiety models and on serotonergic neural transmission in rats. J Pharmacol Sci. 2015 Jan;127(1):109-16. DOI:10.1016/j.jphs.2014.11.008
AP521 Preparation Products And Raw materials
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