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| | MMP-3 INHIBITOR VIII Basic information |
| Product Name: | MMP-3 INHIBITOR VIII | | Synonyms: | MMP-3 INHIBITOR VIII;N-HYDROXY-2(R)-[[(4-METHOXYPHENYL)SULFONYL]-[BENZYLAMINO]-4-METHYLPENTANAMIDE;2-[benzyl-(4-methoxyphenyl)sulfonylamino]-N-hydroxy-4-methylpentanamide;Pentanamide, N-hydroxy-2-[[(4-methoxyphenyl)sulfonyl](phenylmethyl)amino]-4-methyl-;MMP3 inhibitor 2 | | CAS: | 208663-26-7 | | MF: | C20H26N2O5S | | MW: | 406.5 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | MMP-3 INHIBITOR VIII Chemical Properties |
| density | 1.245±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml | | form | A crystalline solid | | pka | 9.13±0.40(Predicted) |
| | MMP-3 INHIBITOR VIII Usage And Synthesis |
| Description | Matrix metalloproteinases (MMPs) belong to a family of proteases that play a crucial role in tissue remodeling and repair by degrading extracellular matrix proteins to enable cell migration. MMP-3 (also known as stromelysin-1) is thought to play a role in the vascular remodeling that occurs during aneurysm formation and may also be involved in wound repair, progression of atherosclerosis, and tumor initiation. MMP-3 inhibitor VIII is a cell permeable sulfonamide-based hydroxamic acid that binds to the active site of MMP-3 (Ki = 23 nM) and prevents its activity. This compound has also been shown to inhibit mouse macrophage metalloelastase MME/MMP-12 with an IC50 value of 13 nM. | | Uses | MMP12-IN-3 (compound 32) is a potent MMP12 inhibitor with an IC50 value of 4.9 nM. MMP12-IN-3 has the potential for the research of chronic respiratory diseases such as emphysema[1]. | | IC 50 | MMP-12: 4.9 nM (IC50) | | References | [1] Jeng AY, et al. Sulfonamide-based hydroxamic acids as potent inhibitors of mouse macrophage metalloelastase. Bioorg Med Chem Lett. 1998 Apr 21;8(8):897-902. DOI:10.1016/s0960-894x(98)00142-5 |
| | MMP-3 INHIBITOR VIII Preparation Products And Raw materials |
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