CLK inhibitor T3
(T3) manufacturers
- CLK-IN-T3
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- $42.00
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2026-07-27
- CAS:2109805-56-1
- Purity: 99.61%
- Supply Ability: 10g
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| | CLK inhibitor T3
(T3) Basic information |
| Product Name: | CLK inhibitor T3
(T3) | | Synonyms: | CLK inhibitor T3
(T3);CLK-IN-T3;Benzamide, 4-[1,1-dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]-;T3-CLK;CDC-like,Dual specificity tyrosine phosphorylation regulated kinase,inhibit,Dual specificity tyrosine regulated kinase,stable,anti-cancer,DYRK,CLK,kinase,CDK,CLK-IN-T-3,CLKINT3,DYRK1A,Inhibitor,activity,CLK IN T3,DYRK1B,Cyclin dependent kinase;T3 CLK New;CLK-IN-T3, 10 mM in DMSO;4-[1,1-Dimethyl-2-(4-methyl-1-piperazinyl)-2-oxoethyl]-N-[6-(4-pyridinyl)imidazo[1,2-a]pyridin-2-yl]benzamide | | CAS: | 2109805-56-1 | | MF: | C28H30N6O2 | | MW: | 482.58 | | EINECS: | | | Product Categories: | | | Mol File: | 2109805-56-1.mol |  |
| | CLK inhibitor T3
(T3) Chemical Properties |
| density | 1.25±0.1 g/cm3(Predicted) | | storage temp. | room temp | | solubility | DMSO: 2mg/mL, clear (warmed) | | form | Solid | | pka | 4.70±0.46(Predicted) | | color | Off-white to light yellow | | InChIKey | IEFFSHLHNYVSEF-UHFFFAOYSA-N | | SMILES | C(NC1=CN2C(=N1)C=CC(C1C=CN=CC=1)=C2)(=O)C1=CC=C(C(C)(C)C(N2CCN(C)CC2)=O)C=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | CLK inhibitor T3
(T3) Usage And Synthesis |
| Uses | CLK-IN-T3 is a high potent, selective, and stable CDC-like kinase (CLK) inhibitor with IC50s of 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases, respectively. CLK-IN-T3 has anti-cancer activity[1]. | | Biological Activity | T3-CLK (T3) is a cell permeable, highly potent and selective cell-base stable inhibitor of CDC-like kinase (CLK) th at exhibits dose-dependent alternative splicing effects in HCT116 colorectal cancer cells. T3-CLK increases conjoined gene (CG) transcription. | | IC 50 | CLK1: 0.67 nM (IC50); CLK2: 15 nM (IC50); CLK3: 110 nM (IC50); DYRK1A: 260 nM (IC50); DYRK1B: 230 nM (IC50) | | References | [1] Funnell T, et al. CLK-dependent exon recognition and conjoined gene formation revealed with a novel smallmolecule inhibitor. Nat Commun. 2017 Feb 23;8(1):7. DOI:10.1038/s41467-016-0008-7 |
| | CLK inhibitor T3
(T3) Preparation Products And Raw materials |
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