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| | KAR-5417
(KAR5417) Basic information |
| Product Name: | KAR-5417
(KAR5417) | | Synonyms: | KAR-5417
(KAR5417);2,8-Diazaspiro[4.5]decane-3-carboxylic acid, 8-[2-amino-6-[(1R)-1-(5-chloro[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, (3S)- | | CAS: | 1673568-73-4 | | MF: | C27H27ClF3N5O3 | | MW: | 561.98 | | EINECS: | | | Product Categories: | | | Mol File: | 1673568-73-4.mol |  |
| | KAR-5417
(KAR5417) Chemical Properties |
| Boiling point | 770.3±70.0 °C(Predicted) | | density | 1.47±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 2.40±0.20(Predicted) | | color | White to off-white |
| | KAR-5417
(KAR5417) Usage And Synthesis |
| Uses | KAR 5417 is used in the method for treating interstitial lung disease using a tryptophan hydroxylase inhibitor. | | in vivo | Rodatristat (10-50 mg/kg; oral administration; mice) treatment decreases intestinal 5-HT concentrations at 50 mg/kg, their efficacy drop off significantly at the lower 10 mg/kg dose[1]. | Animal Model: | Mice[1] | | Dosage: | 10 mg/kg and 50 mg/kg | | Administration: | Oral administration | | Result: | Decreased intestinal 5-HT concentrations at 50 mg/kg, their efficacy dropped off significantly at the lower 10 mg/kg dose.
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| | IC 50 | TPH1: 33 nM (IC50); TPH2: 7 nM (IC50); serotonin |
| | KAR-5417
(KAR5417) Preparation Products And Raw materials |
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