| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
NVS-ZP7-4 manufacturers
- NVS-ZP7-4
-
- $65.00
-
2026-07-15
- CAS:2349367-89-9
- Purity: 99.86%
- Supply Ability: 10g
- NVS-ZP7-4
-
- $65.00
-
2026-07-15
- CAS:2349367-89-9
- Purity: 99.86%
- Supply Ability: 10g
|
| | NVS-ZP7-4 Basic information |
| Product Name: | NVS-ZP7-4 | | Synonyms: | NVS-ZP7-4;Spiro[piperidine-4,4'(1'H)-quinazolin]-2'(3'H)-one, 1-[(2S)-2-[(6-fluoro-2-benzothiazolyl)amino]-3-phenylpropyl]-;Inhibitor,NVS-ZP-7-4,inhibit,NVSZP74,NVS ZP7 4;NVS-ZP7-4, 10 mM in DMSO;(S)-1-(2-((6-Fluorobenzo[d]thiazol-2-yl)amino)-3-phenylpropyl)-1'H-spiro[piperidine-4,4'-quinazolin]-2'(3'H)-one | | CAS: | 2349367-89-9 | | MF: | C28H28FN5OS | | MW: | 501.62 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 2349367-89-9.mol |  |
| | NVS-ZP7-4 Chemical Properties |
| storage temp. | -20°C, protect from light | | solubility | DMSO: soluble; Ethanol: soluble | | form | A solid | | color | Light yellow to yellow | | InChIKey | FZOFDZMKSAUTHT-NRFANRHFSA-N | | SMILES | Fc1cc2[s]c(nc2cc1)N[C@H](CN4CCC5(NC(=O)Nc6c5cccc6)CC4)Cc3ccccc3 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | NVS-ZP7-4 Usage And Synthesis |
| Uses | NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin (HY-15763)-induced cell death[1][2]. | | Biological Activity | NVS-ZP7-4 is a potent inhibitor of the Notch signaling pathway th at induces endoplasmic reticulum (ER) stress and induces apoptosis in T-ALL cell lines. NVS-ZP7-4 is a potent and selective inhibitor of SLC39A7 (ZIP7) zinc transporter th at increases ER zinc levels. | | References | [1] Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15(2):179-188. DOI:10.1038/s41589-018-0200-7
[2] Chen PH, et al. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021 Feb 19;12(2):198. DOI:10.1038/s41419-021-03482-5 |
| | NVS-ZP7-4 Preparation Products And Raw materials |
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