Hydralazine-D4 Hydrochloride

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Company Name: ChemeGen  
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Company Name: Shanghai Yifei Biotechnology Co. , Ltd.  
Tel: 021-65675885 18964387627
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Company Name: TLC Pharmaceutical Standards Ltd.  
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Email: chinasales04@tlcstandards.com.cn
Company Name: SIMSON PHARMA LIMITED  
Tel: +91-8291074273
Email: k.das@simsonpharma.com

Hydralazine-D4 Hydrochloride manufacturers
Hydralazine-D4 Hydrochloride Basic information
Product Name:Hydralazine-D4 Hydrochloride
Synonyms:Hydralazine-D4 Hydrochloride;Hydralazine-d4 HCl (Dihydralazine EP Impurity C-d4 HCl)
CAS:2749234-32-8
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
Hydralazine-D4 Hydrochloride Structure
Hydralazine-D4 Hydrochloride Chemical Properties
solubility DMSO: soluble
Methanol:
Water: (1:1): soluble
Safety Information
MSDS Information
Hydralazine-D4 Hydrochloride Usage And Synthesis
UsesHydralazine-d4 hydrochloride is the deuterium labeled Hydralazine hydrochloride. Hydralazine hydrochloride is a direct-acting vasodilator that is used as an antihypertensive agent.
References[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Bourreli, B., et al., Additive effects of dihydralazine during enflurane or isoflurane hypotensive anaesthesia for spinal fusion. Can J Anaesth, 1988. 35(3 ( Pt 1)): p. 242-8. DOI:10.1007/BF03010617
[3] Kandler, M.R., et al., Hydralazine for essential hypertension. Cochrane Database Syst Rev, 2010(8): p. CD004934. DOI:10.1002/14651858.CD004934.pub3
[4] JAY N. COHN MD  Alexander M S M  Gordon T McInnes MD. Direct-Acting Vasodilators[J]. Journal of Clinical Hypertension, 2011, 13 9: 690-692. DOI: 10.1111/j.1751-7176.2011.00507.x
[5] E. CORNACCHIA. Hydralazine and procainamide inhibit T cell DNA methylation and induce autoreactivity.[J]. Journal of immunology, 1988, 140 7 1: 2197-2200. DOI: 10.4049/jimmunol.140.7.2197
[6] JOSÉ M LEIRO . Antioxidant activity and inhibitory effects of hydralazine on inducible NOS/COX-2 gene and protein expression in rat peritoneal macrophages[J]. International immunopharmacology, 2004, 4 2: Pages 163-177. DOI: 10.1016/j.intimp.2003.10.004
[7] F ORALLO. Comparison of the effects of hydralazine and nifedipine on contractions and 45Ca influx of rat aorta.[J]. Journal of Pharmacy and Pharmacology, 1991, 43 5: 356-359. DOI: 10.1111/j.2042-7158.1991.tb06704.x
[8] ANEES A. SIDDIQUI . Triazole incorporated pyridazinones as a new class of antihypertensive agents: Design, synthesis and in vivo screening[J]. Bioorganic & Medicinal Chemistry Letters, 2011, 21 3: Pages 1023-1026. DOI: 10.1016/j.bmcl.2010.12.028
Hydralazine-D4 Hydrochloride Preparation Products And Raw materials
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Amlodipine d4 Maleate 9 (Racemic) WBAZQELGBFQHPE-HGSONKNXSA-N Hydralazine hydrochloride Gliclazide-d4 (+)-Nebivolol-d4 Hydrochloride Sodium dichloroacetate