Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]-

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Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]- Suppliers list
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Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]- Basic information
Product Name:Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]-
Synonyms:Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]-;BI-4924;BI4924,BI 4924;2-{4-[(1S)-1-[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)formamido]-2-hydroxyethyl]benzenesulfonyl}acetic acid
CAS:2244452-09-1
MF:C21H20Cl2N2O6S
MW:499.36
EINECS:
Product Categories:APIs
Mol File:2244452-09-1.mol
Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]- Structure
Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]- Chemical Properties
Boiling point 860.6±65.0 °C(Predicted)
density 1.52±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
pka2.51±0.10(Predicted)
color Off-white to yellow
Safety Information
MSDS Information
Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]- Usage And Synthesis
UsesBI-4924 is a lipophilic, highly plasma protein bound selective phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=3 nM) with excellent microsomal, as well as hepatocytic stability. Intracellular trapping of BI-4924 disrupts serine biosynthesis with an IC50 of 2200 nM at 72 h[1].
References[1] Weinstabl H, et al. Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis. J Med Chem. 2019 Jul 31. DOI:10.1021/acs.jmedchem.9b00718
Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]- Preparation Products And Raw materials
Tag:Acetic acid, 2-[[4-[(1S)-1-[[(4,5-dichloro-1,6-dimethyl-1H-indol-2-yl)carbonyl]amino]-2-hydroxyethyl]phenyl]sulfonyl]-(2244452-09-1) Related Product Information
PHGDH-IN-2 PHGDH-IN-6 Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]- 4-[[4-(1H-benzimidazol-2-yl)phenyl]amino]-4-keto-butyric acid PHGDH-inactive BI-4916