Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]-

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Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]- manufacturers

  • PHGDH-IN-3
  • PHGDH-IN-3 pictures
  • $98.00
  • 2026-07-15
  • CAS:2893778-31-7
  • Purity: 99.08%
  • Supply Ability: 10g
Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]- Basic information
Product Name:Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]-
Synonyms:Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]-;PHGDH-IN-3;4-(N-(3-Acetylphenyl)sulfamoyl)-N-(4-(3-fluorophenyl)thiazol-2-yl)benzamide
CAS:2893778-31-7
MF:C24H18FN3O4S2
MW:495.55
EINECS:
Product Categories:
Mol File:2893778-31-7.mol
Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]- Structure
Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]- Chemical Properties
density 1.452±0.06 g/cm3(Predicted)
pka6.29±0.50(Predicted)
form Solid
color Off-white to light brown
Safety Information
MSDS Information
Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]- Usage And Synthesis
UsesPHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC50 value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer[1].
in vivo

PHGDH-IN-3 (compound D8) (p.o., i.v.; 1, 3 mg/kg) exhibits excellent in vivo pharmacokinetic properties[1].
PHGDH-IN-3 (i.p.; 12.5, 25, 50 mg/kg; once daily for consecutive 31 days) exertes evident antitumor efficacy in the PC9 xenograft mouse model[1].

Animal Model:ICR mice[1]
Dosage:1, 3 mg/kg
Administration:Oral (p.o.) and intravenous (i.v.) administration
Result:
PK parametersi.v. (1 mg/kg)p.o. (3 mg/kg)
AUC (hng/mL)38,358 ± 14,76894,386 ± 23,416
T1/2(h)4.94 ± 0.384.74 ± 0.30
Tmax (h)3.33 ± 1.15
CL_obs(mL/min/kg)0.48 ± 0.23
Cmax(ng/mL) 8842 ± 1755
F (%)82.0
Animal Model:Balb/c nude mice[1]
Dosage:12.5, 25, 50 mg/kg
Administration:Intraperitoneal (i.p.); once daily for consecutive 31 days
Result:Exhibited an in vivo anti-tumor effect and significantly delayed the tumor growth.
Significantly abated the tumor weights of mice at 25 mg/ kg.
References[1] Dingding Gao, et al. Discovery of Novel Drug-like PHGDH Inhibitors to Disrupt Serine Biosynthesis for Cancer Therapy. J Med Chem. 2023 Jan 12;66(1):285-305. DOI:10.1021/acs.jmedchem.2c01202
Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]- Preparation Products And Raw materials
Tag:Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]-(2893778-31-7) Related Product Information
Benzamide, 4-[[(3-acetylphenyl)amino]sulfonyl]-N-[4-(3-fluorophenyl)-2-thiazolyl]- ML364 4-(N,N-dimethylsulfamoyl)-N-(4-(naphthalen-1-yl)thiazol-2-yl)benzamide 4-(N,N-dimethylsulfamoyl)-N-(4-(pyridin-4-yl)thiazol-2-yl)benzamide HA-15 PHGDH-IN-2