8pyDTZ
| 中文名称 | 8pyDTZ |
|---|---|
| 中文同义词 | 化合物 T19167;化合物 8PYDTZ |
| 英文名称 | 8pyDTZ |
| 英文同义词 | 8pyDTZ;Imidazo[1,2-a]pyrazin-3(7H)-one, 6-phenyl-2-(phenylmethyl)-8-(4-pyridinyl)- |
| CAS号 | 2351898-91-2 |
| 分子式 | C24H18N4O |
| 分子量 | 378.43 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2351898-91-2.mol |
| 结构式 |  |
8pyDTZ 性质
| 沸点 | 556.7±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.26±0.1 g/cm3(Predicted) |
| 储存条件 | Store at -20°C,unstable in solution, ready to use. |
| 溶解度 | DMSO：12.5 mg/mL（33.03 mM；DMSO 可以灭活 8pyDTZ 的活性）； EtOH+HCl：2 mg/mL（5.28 mM；超声波并用1M HCl调节pH至2；DMSO可以灭活8pyDTZ的活性） |
| 形态 | 固体 |
| 酸度系数(pKa) | 6.54±0.10(Predicted) |
| 颜色 | 浅棕色至棕色 |
| 水溶解性 | Water: < 0.1 mg/mL (insoluble; DMSO can inactivate 8pyDTZ's activity) |
Compared to DTZ, 8pyDTZ (compounds 3c) is able to emit red-shifted chemiluminescence or bioluminescence. 8pyDTZ shows the most red-shifted emission and red-shifted photons can penetrate through tissue better.
LumiLuc-8pyDTZ in human embryonic kidney (HEK) 293T cells transiently expressing the luciferase is evaluated. The LumiLuc-8pyDTZ pair produces ∼3-5-fold more bioluminescence than teLuc-8pyDTZ. To compare far-red emission intensities of bioluminescent reporters, HEK 293T cells in the presence of a 600-700 nm band pass filter are imaged. At substrate concentrations from 6.25 to 100 μM, LumiLuc-8pyDTZ consistently produces 1.6-3.9-fold higher photon flux than teLuc-DTZ. No ATP perturbation is observed from 8pyDTZ-treated, LumiLucexpressing cells.
LumiLuc-8pyDTZ pair is compared with several benchmark reporters in a tumor xenograft mouse model. LumiLuc-8pyDTZ shows high sensitivity and does not need organic cosolvents for in vivo administration. LumiScarlet-8pyDTZ is comparable to Akaluc-AkaLumine, the brightest ATP-dependent luciferase-luciferin pair, for detecting cells in deep tissues of mice.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-135368 | 8pyDTZ | 2351898-91-2 | 1 mg | 2045元 |
| 2025/12/22 | HY-135368 | 8pyDTZ 8pyDTZ | 2351898-91-2 | 5mg | 4500元 |