8pyDTZ manufacturers
- 8pyDTZ
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2026-07-15
- CAS:2351898-91-2
- Purity:
- Supply Ability: 10g
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| Product Name: | 8pyDTZ | | Synonyms: | 8pyDTZ;Imidazo[1,2-a]pyrazin-3(7H)-one, 6-phenyl-2-(phenylmethyl)-8-(4-pyridinyl)- | | CAS: | 2351898-91-2 | | MF: | C24H18N4O | | MW: | 378.43 | | EINECS: | | | Product Categories: | | | Mol File: | 2351898-91-2.mol |  |
| | 8pyDTZ Chemical Properties |
| Boiling point | 556.7±60.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C,unstable in solution, ready to use. | | solubility | DMSO: 12.5 mg/mL (33.03 mM; DMSO can inactivate 8pyDTZ's activity); EtOH+HCl: 2 mg/mL (5.28 mM; ultrasonic and adjust pH to 2 with 1M HCl; DMSO can inactivate 8pyDTZ's activity) | | form | Solid | | pka | 6.54±0.10(Predicted) | | color | Light brown to brown | | Water Solubility | Water: < 0.1 mg/mL (insoluble; DMSO can inactivate 8pyDTZ's activity) |
| | 8pyDTZ Usage And Synthesis |
| Uses | 8pyDTZ is a pyridyl diphenylterazine (DTZ) analog and an ATP-independent pyridyl substrate of LumiLuc luciferase. 8pyDTZ exhibits spectrally shifted emission. 8pyDTZ has excellent biocompatibility and superior in vivo sensitivity. 8pyDTZ can be used for in vivo luminescence imaging[1]. | | in vivo | LumiLuc-8pyDTZ pair is compared with several benchmark reporters in a tumor xenograft mouse model. LumiLuc-8pyDTZ shows high sensitivity and does not need organic cosolvents for in vivo administration. LumiScarlet-8pyDTZ is comparable to Akaluc-AkaLumine, the brightest ATP-dependent luciferase-luciferin pair, for detecting cells in deep tissues of mice[1]. | | References | [1] Yeh HW, et al. ATP-Independent Bioluminescent Reporter Variants To Improve in Vivo Imaging. ACS Chem Biol. 2019 May 17;14(5):959-965. DOI:10.1021/acschembio.9b00150 |
| | 8pyDTZ Preparation Products And Raw materials |
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