(E)-cyclooct-4-enol / axial - TCO4 / A

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(E)-cyclooct-4-enol / axial - TCO4 / A Basic information
Product Name:(E)-cyclooct-4-enol / axial - TCO4 / A
Synonyms:(E)-cyclooct-4-enol / axial - TCO4 / A;(E)-cyclooct-4-enol / axial - TCO / A;(R)-TCO-OH;4-Cycloocten-1-ol, (1R)-;(R)-Cyclooct-4-en-1-ol
CAS:39637-78-0
MF:C8H14O
MW:126.2
EINECS:
Product Categories:SiChem
Mol File:39637-78-0.mol
(E)-cyclooct-4-enol / axial - TCO4 / A Structure
(E)-cyclooct-4-enol / axial - TCO4 / A Chemical Properties
Boiling point 202.2±29.0 °C(Predicted)
density 0.954±0.06 g/cm3(Predicted)
pka15.13±0.20(Predicted)
Safety Information
MSDS Information
(E)-cyclooct-4-enol / axial - TCO4 / A Usage And Synthesis
Uses(R)-TCO-OH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. (R)-TCO-OH is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.
IC 50Alkyl-Chain
References[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
(E)-cyclooct-4-enol / axial - TCO4 / A Preparation Products And Raw materials
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