NEUROPEPTIDE Y (13-36), HUMAN, RAT

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NEUROPEPTIDE Y (13-36), HUMAN, RAT manufacturers
NEUROPEPTIDE Y (13-36), HUMAN, RAT Basic information
Product Name:NEUROPEPTIDE Y (13-36), HUMAN, RAT
Synonyms:L-Pro-L-Ala-L-Glu-L-Asp-L-Met-L-Ala-L-Arg-L-Tyr-L-Tyr-L-Ser-L-Ala-L-Leu-L-Arg-L-His-L-Tyr-L-Ile-L-Asp(NH2)-L-Leu-L-Ile-L-Thr-L-Arg-L-Gln-L-Arg-L-Tyr-NH2;Neuropeptide Y(13-36)【rat】;TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2: YPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRY-NH2;REF DUPL: H-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2;H-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2;NPY (13-36) (HUMAN, RAT);NEUROPEPTIDE Y (13-36) HUMAN;NEUROPEPTIDE Y (13-36), HUMAN, RAT
CAS:122341-40-6
MF:C134H207N41O36S
MW:3000.4
EINECS:
Product Categories:Peptide
Mol File:122341-40-6.mol
NEUROPEPTIDE Y (13-36), HUMAN, RAT Structure
NEUROPEPTIDE Y (13-36), HUMAN, RAT Chemical Properties
density 1.49±0.1 g/cm3(Predicted)
storage temp. -15°C
solubility Soluble in DMSO
form Solid
color White to off-white
SequencePro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH2
Safety Information
MSDS Information
NEUROPEPTIDE Y (13-36), HUMAN, RAT Usage And Synthesis
UsesNeuropeptide Y (13-36), amide, human is a selectiveneuropeptide Y2 receptoragonist[1].
in vivo

Neuropeptide Y (13-36) (intraventricular injection; 25-3000 pmol) produces a dose-dependent increase (up to 14%; ED50 value of 0.3 nmol for overall effects and 0.97 nmol for the peak effects) in mean arterial blood pressure in the awake, unrestrained male rat without affecting heart rate. Central administration of porcine Neuropeptide Y (13-36) produces marked vasodepressor and bradycardic actions in the anaesthetized α-chloralose and in the awake unrestrained male rat[1].Neuropeptide Y (13-36) (intracerebroventricular injection; 50 ng; alone; injected 30 and 15 min before measurements) injected into nave mice impairs social novelty preference, but not sociability, and this effect is inhibited by the NPY Y2 receptor antagonist BIIE 0246[2].

Animal Model:Male ICR mice (age 4-7 weeks)[2]
Dosage:50 ng/mouse
Administration:Intracerebroventricular injection
Result:Significantly decreased interaction time with the new stranger mouse in session 3 that NPY 13-36.
IC 50NPY Y2 receptor
References[1] Aguirre JA, et al. Centrally injected neuropeptide Y (13-36) produces vasopressor effects and antagonizes the vasodepressor action of neuropeptide Y (1-36) in the awake male rat. Neurosci Lett. 1990 Oct 2;118(1):5-8. DOI:10.1016/0304-3940(90)90235-2
[2] Daiki Ueda, et al. Increase in neuropeptide Y activity impairs social behaviour in association with glutamatergic dysregulation in diabetic mice. Br J Pharmacol. 2021 Feb;178(3):726-740. DOI:10.1111/bph.15326
NEUROPEPTIDE Y (13-36), HUMAN, RAT Preparation Products And Raw materials
Tag:NEUROPEPTIDE Y (13-36), HUMAN, RAT(122341-40-6) Related Product Information
NEUROPEPTIDE SF (HUMAN) SALBUTAMOL H-TRP-TYR-LYS-HIS-VAL-ALA-SER-PRO-ARG-TYR-HIS-THR-VAL-GLY-ARG-ALA-ALA-GLY-LEU-LEU-MET-GLY-LEU-OH H-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2 NEUROPEPTIDE W-30 (HUMAN) ATRIAL NATRIURETIC PEPTIDE (126-149) (RAT) GIP (3 - 42), human NEUROPEPTIDE AF (HUMAN) NEUROPEPTIDE Y (13-36) (PORCINE) H-TYR-PRO-SER-LYS-PRO-ASP-ASN-PRO-GLY-GLU-ASP-ALA-PRO-ALA-GLU-ASP-MET-ALA-ARG-TYR-TYR-SER-ALA-LEU-NH2 NEI-GRR-MCH (HUMAN, MOUSE, RAT) NEUROPEPTIDE VF (56-92) (HUMAN) H-VAL-PRO-ASN-LEU-PRO-GLN-ARG-PHE-NH2 ADRENOMEDULLIN (26-52) (HUMAN) PRO-GLN-ARG-PHE-AMIDE TRIFLUOROACETATE SALT H-SER-ALA-LEU-ARG-HIS-TYR-ILE-ASN-LEU-ILE-THR-ARG-GLN-ARG-TYR-NH2 (LEU31,PRO34)-NEUROPEPTIDE Y (13-36) (HUMAN, RAT) NEUROPEPTIDE Y (13-36), HUMAN, RAT , TAMRA-LABELED