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2H-1,3-Benzoxazine-2,4(3H)-dione

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Company Name: CHANGZHOU HARVECHEM LTD
Tel: +86-0519-88784888 +8613906120163
Email: inquiry@harvechem.com
Products Intro: Product Name:2H-1,3-Benzoxazine-2,4(3H)-dione;Carsalam
CAS:2037-95-8
Purity:0.98
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:2H-1,3-benzoxazine-2,4(3H)-dione
CAS:2037-95-8
Purity:NLT 98% Package:1G;1KG;100KG
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
Tel: +86-2158073036
Email: info@dakenam.com
Products Intro: Product Name:Kasaron
CAS:2037-95-8
Purity:0.99 Package:5KG;1KG
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: CAS:2037-95-8
Purity:0.99 Package:5G，10G，25G，50G，100G，250G,1KG
Company Name: Alchem Pharmtech,Inc.
Tel: 8485655694
Email: sales@alchempharmtech.com
Products Intro: Product Name:2H-Benzo[e][1,3]oxazine-2,4(3H)-dione
CAS:2037-95-8
Purity:97+% Package:1g;10g;100g;;1kg Remarks:Z-30649

2H-1,3-Benzoxazine-2,4(3H)-dione manufacturers

  • Carsalam
  • Carsalam pictures
  • $29.00 / 1mL
  • 2026-03-13
  • CAS:2037-95-8
  • Min. Order:
  • Purity: 99.84%
  • Supply Ability: 10g
  • Carsalam
  • Carsalam pictures
  • $29.00 / 1mL
  • 2026-03-13
  • CAS:2037-95-8
  • Min. Order:
  • Purity: 99.84%
  • Supply Ability: 10g
2H-1,3-Benzoxazine-2,4(3H)-dione Basic information
Product Name:2H-1,3-Benzoxazine-2,4(3H)-dione
Synonyms:beaprine;carsalam;oxophenhydroxazine;ruhmal;TIMTEC-BB SBB003929;1,3-BENZOXAZINE-2,4-DIONE;2H-1,3-Benzoxazine-2,4(3H)-dione 98%;CAS:2037-95-8
CAS:2037-95-8
MF:C8H5NO3
MW:163.13
EINECS:606-541-4
Product Categories:Benzoxazines;Building Blocks;Heterocyclic Building Blocks
Mol File:2037-95-8.mol
2H-1,3-Benzoxazine-2,4(3H)-dione Structure
2H-1,3-Benzoxazine-2,4(3H)-dione Chemical Properties
Melting point 228-232 °C(lit.)
density 1.402±0.06 g/cm3(Predicted)
vapor pressure 0.73-1.27Pa at 89.94-107.94℃
storage temp. Sealed in dry,Room Temperature
solubility DMSO : ≥ 40 mg/mL (245.20 mM)
form Solid
pka9.16±0.20(Predicted)
color White to off-white
Merck 13,1879
InChIInChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)12-8(11)9-7/h1-4H,(H,9,10,11)
InChIKeyOAYRYNVEFFWSHK-UHFFFAOYSA-N
SMILESO1C2=CC=CC=C2C(=O)NC1=O
LogP0.78-0.88 at 20℃
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 36
WGK Germany 3
RTECS DM3110000
HS Code 2934999090
Storage Class11 - Combustible Solids
Hazard ClassificationsAcute Tox. 4 Oral
MSDS Information
2H-1,3-Benzoxazine-2,4(3H)-dione Usage And Synthesis
Chemical PropertiesOff-white to light brown crystalline powder
Usesanalgesic
DefinitionChEBI: Carsalam is a benzoxazine.
General DescriptionKinetic studies of the alkaline hydrolysis of 2H-1,3-benzoxazine-2,4(3H)-dione (carsalam) were conducted and reaction was found to be of fractional order with respect to [OH-].
Synthesis2H-1,3-Benzoxazine-2,4(3H)-dione was prepared according to the procedure of Hoback, Crum and Carroll. To a solution of 411 g. (3. 0 moles) salicylamide in 483 ml. (6.0 moles) of anhydrous pyridine at 0℃ was added slowly with stirring 572 ml. (6.0 moles) of ethyl chlorocarbonate. The resulting orange solution was refluxed for 5 hr. and poured into 2L of ice water. The filtered product was washed twice with 0.5L of water and recrystallized three times from acetone-ethanol (50: 50), giving white needles 2H-1,3-Benzoxazine-2,4(3H)-dione (83% yield), m.p. 227.5-228.5° (lit. 12), m.p. 227-228°, which gave no coloration with ethanolic ferric chloride[1].
References[1] J. D. Crum, J. A. Franks Jr. “The chemistry of heterocycles. III. 2H-1,3-benzoxazine-2,4(3H)-dione and Some 3-substituted derivatives..” Journal of Heterocyclic Chemistry 2 1 (1965): 37–40.
Tag:2H-1,3-Benzoxazine-2,4(3H)-dione(2037-95-8) Related Product Information
3-[2-(Diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione 6-Chloro-2H-3,1-benzoxazine-2,4(1H)-dione,6-Chloro-4H-3,1-benzoxazine-2(1H),4-dione,6-chloro-4h-3,1-benzoxazine-2,4(1h)-dione 7-METHOXY-1,3-BENZOXAZINE-2,4-DIONE Isatoic Anhydride N-methylisatoic anhydride 6-chloro-1-methyl-2H-3,1-benzoxazine-2,4(1H)-dione 2H-1,3-Benzoxazine-2,4(3H)-dione 6-BROMO-2H-BENZO[E][1,3]OXAZINE-2,4(3H)-DIONE 8-Hydroxy-2H-1,3-benzoxazine-2,4(3H)-dione 6-Hydroxy-2H-3,1-benzoxazine-2,4(1H)-dione 3-Methyl-2H-1,3-benzoxazine-2,4(3H)-dione 2H-1,4-BENZOXAZINE-2,3(4H)-DIONE 3-OXIME 6-METHYL-2H-1,4-BENZOXAZINE-2,3(4H)-DIONE 3-OXIME 6-CHLORO-2H-1,4-BENZOXAZINE-2,3(4H)-DIONE 3-OXIME 5-Nitro-2H-3,1-benzoxazine-2,4(1H)-dione 7-Methyl-2H-1,3-benzoxazine-2,4(3H)-dione 5-FLUORO-2H-3,1-BENZOXAZINE-2,4(1H)-DIONE 2H-1,4-benzoxazine-2,3(4H)-dione