| Company Name: |
Abydos Scientific Gold |
| Tel: |
18936879710 18851749494 |
| Email: |
sales@abydoscientific.com |
- Carsalam
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- $29.00
-
2026-05-11
- CAS:2037-95-8
- Purity: 99.84%
- Supply Ability: 10g
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| | 2H-1,3-Benzoxazine-2,4(3H)-dione Basic information |
| | 2H-1,3-Benzoxazine-2,4(3H)-dione Chemical Properties |
| Melting point | 228-232 °C(lit.) | | density | 1.402±0.06 g/cm3(Predicted) | | vapor pressure | 0.73-1.27Pa at 89.94-107.94℃ | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO : ≥ 40 mg/mL (245.20 mM) | | form | Solid | | pka | 9.16±0.20(Predicted) | | color | White to off-white | | Merck | 13,1879 | | InChI | InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)12-8(11)9-7/h1-4H,(H,9,10,11) | | InChIKey | OAYRYNVEFFWSHK-UHFFFAOYSA-N | | SMILES | O1C2=CC=CC=C2C(=O)NC1=O | | LogP | 0.78-0.88 at 20℃ |
| Hazard Codes | Xn | | Risk Statements | 22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | DM3110000 | | HS Code | 2934999090 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral |
| | 2H-1,3-Benzoxazine-2,4(3H)-dione Usage And Synthesis |
| Chemical Properties | Off-white to light brown crystalline powder | | Uses | analgesic | | Definition | ChEBI: Carsalam is a benzoxazine. | | General Description | Kinetic studies of the alkaline hydrolysis of 2H-1,3-benzoxazine-2,4(3H)-dione (carsalam) were conducted and reaction was found to be of fractional order with respect to [OH-]. | | Synthesis | 2H-1,3-Benzoxazine-2,4(3H)-dione was prepared according to the procedure of Hoback, Crum and Carroll. To a solution of 411 g. (3. 0 moles) salicylamide in 483 ml. (6.0 moles) of anhydrous pyridine at 0℃ was added slowly with stirring 572 ml. (6.0 moles) of ethyl chlorocarbonate. The resulting orange solution was refluxed for 5 hr. and poured into 2L of ice water. The filtered product was washed twice with 0.5L of water and recrystallized three times from acetone-ethanol (50: 50), giving white needles 2H-1,3-Benzoxazine-2,4(3H)-dione (83% yield), m.p. 227.5-228.5° (lit. 12), m.p. 227-228°, which gave no coloration with ethanolic ferric chloride[1]. | | References | [1] J. D. Crum, J. A. Franks Jr. “The chemistry of heterocycles. III. 2H-1,3-benzoxazine-2,4(3H)-dione and Some 3-substituted derivatives..” Journal of Heterocyclic Chemistry 2 1 (1965): 37–40.
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| | 2H-1,3-Benzoxazine-2,4(3H)-dione Preparation Products And Raw materials |
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