1-Naphthylacetyl spermine trihydrochloride

1-Naphthylacetyl spermine trihydrochloride Suppliers list

Company Name:	Shanghai Beckham Medical Technology Co., Ltd Gold
Tel:	13816613772
Email:	huahero21@sina.com

Company Name:	Chemsky（shanghai）International Co.,Ltd.
Tel:	021-50135380
Email:	shchemsky@sina.com

1-Naphthylacetyl spermine trihydrochloride manufacturers

1-Naphthylacetyl spermine trihydrochloride Basic information

Product Name:	1-Naphthylacetyl spermine trihydrochloride
Synonyms:	NASPM (hydrochloride);1-Naphthyl acetyl spermine (NASPM) trihydrochloride;Naspm trihydrochloride (1-Naphthylacetyl spermine);inhibit,Inhibitor,Naspm trihydrochloride,iGluR,Ionotropic glutamate receptors;N-(3-((4-((3-Aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride;Naspm trihydrochloride, 10 mM in DMSO;Naspm trihydrochloride (1-Naphthylacetyl spermine trihydrochloride);Naspm 3HCl
CAS:	1049731-36-3
MF:	C22H35ClN4O
MW:	407
EINECS:
Product Categories:	Amines;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:	Mol File

1-Naphthylacetyl spermine trihydrochloride Chemical Properties

Melting point	>253°C (dec.)
storage temp.	desiccated protect from light
solubility	H₂O: 23 mg/mL
form	solid
color	white
Water Solubility	Soluble in water (100mM)
InChI	InChI=1S/C22H34N4O.ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);1H
InChIKey	IFFNMWLDPXWOIH-UHFFFAOYSA-N
SMILES	C(C1=CC=CC2C=CC=CC1=2)C(=O)NCCCNCCCCNCCCN.Cl

Safety Information

MSDS Information

Provider	Language
SigmaAldrich	English

1-Naphthylacetyl spermine trihydrochloride Usage And Synthesis

Chemical Properties	White Solid
Uses	1-Naphthylacetyl Spermine Trihydrochloride is a poliamine amide as potent Spermidine uptake inhibitor.
Biological Activity	naspm trihydrochloride is a selective antagonist of ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (ampa) receptors. ampa receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. on excitatory neurons in adult animals, two types of ampa receptors are primarily expressed, namely heteromeric channels composed of glur1 and glur2 subunits (glur1/2 receptors), as well as channels composed of glur2 and glur3 subunits (glur2/3 receptors). naspm trihydrochloride blocks ampa receptors lacking the glur2 subunit, with an ic50 value of 0.3 μm for glur1 homomers.1. nilsen a, england pm. a subtype-selective, use-dependent inhibitor of native ampa receptors. journal of the american chemical society, 2007, 129(16): 4902-4903.2. koike m, iino m, ozawa s. blocking effect of 1-naphthyl acetyl spermine on ca2+-permeable ampa receptors in cultured rat hippocampal neurons. neuroscience research, 1997, 29(1): 27-36.
Biochem/physiol Actions	Blocks Ca2+ permeable AMPA receptor channels.
storage	+4°C (desiccate)

1-Naphthylacetyl spermine trihydrochloride Preparation Products And Raw materials

Tag:1-Naphthylacetyl spermine trihydrochloride(1049731-36-3) Related Product Information

Bis(3-aminopropyl) ether Aminosilane Benzeneacetamide, N-(4-aminocyclohexyl)- Benzeneacetamide, N-butyl- 4-piperidinamine, 1-(phenylacetyl)- N-(3-aminopropyl)-3-(m-tolyl)propanamide hydrochloride