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| | Z-FY-CHO Basic information |
| Product Name: | Z-FY-CHO | | Synonyms: | CATHEPSIN L INHIBITOR II;Z-Phe-Tyr-al;Z-PHE-TYR-ALDEHYDE;Z-PHE-TYR-CHO;Z-FY-CHO;Carbamic acid, N-[(1S)-2-[[(1S)-1-formyl-2-(4-hydroxyphenyl)ethyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-, phenylmethyl ester;Z-L-PHE-L-TYR-ALDEHYDE;Cathepsin L inhibitor inhibitor | | CAS: | 167498-29-5 | | MF: | C26H26N2O5 | | MW: | 446.49 | | EINECS: | | | Product Categories: | | | Mol File: | 167498-29-5.mol |  |
| | Z-FY-CHO Chemical Properties |
| Boiling point | 726.5±60.0 °C(Predicted) | | density | 1.249±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml) | | pka | 9.87±0.15(Predicted) | | form | solid | | color | Off-white to pale yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | Z-FY-CHO Usage And Synthesis |
| Description | Z-Phe-Tyr-CHO (167498-29-5) is a potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2 | | Uses | Z-Phe-Tyr-aldehyde is a cathepsin L inhibitor useful in the study of human osteoclast resorption and drug development for the treatment of coronavirus disease. | | in vivo | Intraperitoneal administration of Z-FY-CHO (2.5-10 mg/kg) for 4 weeks suppresses bone weight loss dose dependently in the ovariectomized mouse, experimental model of osteoporosis. Z-FY-CHO acts as a bone resorption suppressor through the inhibition of collagen degradation[3]. | | IC 50 | cathepsin L | | References | [1] JE-TAE WOO. Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L[J]. Bioorganic & Medicinal Chemistry Letters, 1995, 5 14: Pages 1501-1504. DOI:10.1016/0960-894x(95)00236-m
[2] JE-TAE WOO . Suppressive effect of N-(benzyloxycarbonyl)-l-phenylalanyl-l-tyrosinal on bone resorption in vitro and in vivo[J]. European journal of pharmacology, 1996, 300 1: Pages 131-135. DOI:10.1016/0014-2999(95)00858-6
[3] I E JAMES. Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro.[J]. The Journal of Biological Chemistry, 2001, 276 15: 11507-11511. DOI:10.1074/jbc.m010684200
[4] ALLEN KAASIK. Up-regulation of lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium[J]. European Journal of Neuroscience, 2005, 22 5: 1023-1031. DOI:10.1111/j.1460-9568.2005.04279.x |
| | Z-FY-CHO Preparation Products And Raw materials |
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