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| | Teprotumumab Basic information |
| Product Name: | Teprotumumab | | Synonyms: | Teprotumumab;Research Grade Teprotumumab(DHC29903);Teprotumumab (anti-IGF1R);R 1507|||HZN 001;Research Grade Teprotumumab | | CAS: | 1036734-93-6 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Teprotumumab Structure]() |
| | Teprotumumab Chemical Properties |
| form | Liquid | | color | Colorless to light yellow |
| | Teprotumumab Usage And Synthesis |
| Uses | Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research[1]. | | References | [1] Chen H, et al. Teprotumumab, an IGF-1R blocking monoclonal antibody inhibits TSH and IGF-1 action in fibrocytes. J Clin Endocrinol Metab. 2014 Sep;99(9):E1635-40. DOI:10.1210/jc.2014-1580 |
| | Teprotumumab Preparation Products And Raw materials |
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