Desthiobiotin-PEG3-NHS ester manufacturers
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| | Desthiobiotin-PEG3-NHS ester Basic information |
| Product Name: | Desthiobiotin-PEG3-NHS ester | | Synonyms: | Desthiobiotin-PEG3-NHS ester;rel-2,5-Dioxopyrrolidin-1-yl 19-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)-14-oxo-4,7,10-trioxa-13-azanonadecanoate | | CAS: | 2411681-92-8 | | MF: | C23H38N4O9 | | MW: | 514.57 | | EINECS: | | | Product Categories: | | | Mol File: | 2411681-92-8.mol |  |
| | Desthiobiotin-PEG3-NHS ester Chemical Properties |
| density | 1.26±0.1 g/cm3(Predicted) | | solubility | Soluble in Water, DMSO, DCM, DMF | | pka | 14.93±0.60(Predicted) |
| | Desthiobiotin-PEG3-NHS ester Usage And Synthesis |
| Description | Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015 M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin. | | Uses | Desthiobiotin-PEG3-NHS ester is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd = 1011 vs. 1015 M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. |
| | Desthiobiotin-PEG3-NHS ester Preparation Products And Raw materials |
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