| Company Name: |
TCI Europe |
| Tel: |
320-37350700 |
| Email: |
sales@tcieurope.eu |
| Company Name: |
TCI AMERICA |
| Tel: |
800-4238616 |
| Email: |
sales@tciamerica.com |
Azide-PEG3-Desthiobiotin manufacturers
|
| | Azide-PEG3-Desthiobiotin Basic information |
| Product Name: | Azide-PEG3-Desthiobiotin | | Synonyms: | Azide-PEG3-Desthiobiotin;N-[2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl]-6-[(4R,5S)-5-methyl-2-oxoimidazolidin-4-yl]hexanamide;CAS_1426828-06-9;Desthiobiotin-PEG4-N3;Desthiobiotin-PEG4-Azide | | CAS: | 1426828-06-9 | | MF: | C18H34N6O5 | | MW: | 414.51 | | EINECS: | | | Product Categories: | | | Mol File: | 1426828-06-9.mol |  |
| | Azide-PEG3-Desthiobiotin Chemical Properties |
| storage temp. | Storage temp. 2-8°C | | form | clear liquid | | color | Colorless to Yellow to Orange |
| | Azide-PEG3-Desthiobiotin Usage And Synthesis |
| Description | Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (Kd= 1011vs. 1015M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin. | | Uses | Azide-PEG3-Desthiobiotin is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Desthiobiotin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Azide-PEG3-Desthiobiotin Preparation Products And Raw materials |
|