2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)-

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2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)- Suppliers list
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2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)- manufacturers
2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)- Basic information
Product Name:2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)-
Synonyms:2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)-;TRPV3 74a;(αS)-α-[cis-3-Hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-2-pyridinemethanol;TRPV3 antagonist 74a;TRPV3 antagonist 74a,TRPV-3 antagonist 74a
CAS:1432051-63-2
MF:C17H17F3N2O2
MW:338.33
EINECS:
Product Categories:
Mol File:1432051-63-2.mol
2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)- Structure
2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)- Chemical Properties
Boiling point 447.8±45.0 °C(Predicted)
density 1.377±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO|33.83|100|
pka13.36±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)- Usage And Synthesis
UsesTRPV3 antagonist 74a is a potent and selective TRPV3 antagonist. TRPV3 antagonist 74a displays no significant activity against a panel of other ion channels. TRPV3 antagonist 74a can be used for the research of neuropathic pain[1][2].
in vivo

TRPV3 antagonist 74a (150 μg; intradermal injection; 30 minutes) decreases the number of scratches significantly[2].
. TRPV3 antagonist 74a (10~100 mg/kg; p.o.) dose-dependently attenuates mechanical allodynia induced by von Frey hair stimulation to the ipsilateral (injured) hind paw. TRPV3 antagonist 74a exhibits anti-nociceptive activity in the reserpine model of central pain by increasing muscle pressure threshold[1].

Animal Model:WT mice
Dosage:150 μg
Administration:Intradermal injection; 30 minutes
Result:The number of scratches decreased significantly.
IC 50TRPV3
storageStore at -20°C
References[1] Gomtsyan A, et al. Synthesis and Pharmacology of (Pyridin-2-yl)methanol Derivatives as Novel and Selective Transient Receptor Potential Vanilloid 3 Antagonists. J Med Chem. 2016;59(10):4926-4947. DOI:10.1021/acs.jmedchem.6b00287
[2] Zhao J, et al. PAR2 Mediates Itch via TRPV3 Signaling in Keratinocytes. J Invest Dermatol. 2020;140(8):1524-1532. DOI:10.1016/j.jid.2020.01.012
2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)- Preparation Products And Raw materials
Raw materials3-Methylenecyclobutanecarbonitrile
Tag:2-Pyridinemethanol, α-[cis-3-hydroxy-3-methyl-1-[4-(trifluoromethyl)-2-pyridinyl]cyclobutyl]-, (αS)-(1432051-63-2) Related Product Information
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