化合物 (S)-RO 32-0432
| 中文名称 | 化合物 (S)-RO 32-0432 |
|---|---|
| 中文同义词 | 化合物 (S)-RO 32-0432 |
| 英文名称 | Ro 32-0432 hydrochloride |
| 英文同义词 | (S)-Ro 32-0432 |
| CAS号 | 1781828-85-0 |
| 分子式 | C28H29ClN4O2 |
| 分子量 | 489.02 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1781828-85-0.mol |
| 结构式 |  |
化合物 (S)-RO 32-0432 性质
| 溶解度 | 温和加热时在 DMSO 中溶解至 10 mM |
|---|
|
PKCα 9.3 nM (IC 50 ) |
PKC-βI 28 nM (IC 50 ) |
PKC-βII 30 nM (IC 50 ) |
PKCγ 36.5 nM (IC 50 ) |
PKCε 108.3 nM (IC 50 ) |
G protein-coupled receptor kinase 5 (GRK5)
|
Ro 32-0432 inhibits interleukin-2 (IL-2) secretion, IL-2 receptor expression in, and proliferation of, peripheral human T-cells stimulated with phorbol ester together with phytohemagglutin or anti-CD3, but does not inhibit IL-2 induced proliferation in cells already stimulated to express IL-2 receptors. Proliferation of the influenza peptide antigen HA 307-319-specific human T-cell clone (HA27) after exposure to antigen-pulsed autologous presenting cells is also inhibited by Ro 32-0432. Ro 32-0432 inhibits HA27 proliferation with an IC 50 of 0.15 μM.
Ro 32-0432 (10-50 mg/kg; oral administration; once; female AHH/R rats) treatment inhibits subsequent phorbol ester-induced edema in rats demonstrating the systemic efficacy of the compound to inhibit PKC-driven responses. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Ro 32-0432.
| Animal Model: | Female AHH/R rats (200-250 g) induced with phorbol ester |
| Dosage: | 10 mg/kg, 30 mg/kg, 50 mg/kg |
| Administration: | Oral administration; once |
| Result: | Inhibited subsequent phorbol ester-induced edema in rats. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-108601A | 化合物 (S)-RO 32-0432 (S)-Ro 32-0432 | 1781828-85-0 | 1 mg | 6960元 |