Ro 32-0432 hydrochloride

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Ro 32-0432 hydrochloride Basic information
Product Name:Ro 32-0432 hydrochloride
Synonyms:(S)-Ro 32-0432
CAS:1781828-85-0
MF:C28H29ClN4O2
MW:489.02
EINECS:
Product Categories:
Mol File:1781828-85-0.mol
Ro 32-0432 hydrochloride Structure
Ro 32-0432 hydrochloride Chemical Properties
solubility Soluble to 10 mM in DMSO with gentle warming
Safety Information
MSDS Information
Ro 32-0432 hydrochloride Usage And Synthesis
UsesRo 32-0432 Hydrochloride is a selective inhibitor of PKC.
in vivo

(S)-Ro 32-0432 (10-50 mg/kg; oral administration; once; female AHH/R rats) treatment inhibits subsequent phorbol ester-induced edema in rats demonstrating the systemic efficacy of the compound to inhibit PKC-driven responses. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Ro 32-0432[1].

Animal Model:Female AHH/R rats (200-250 g) induced with phorbol ester[1]
Dosage:10 mg/kg, 30 mg/kg, 50 mg/kg
Administration:Oral administration; once
Result:Inhibited subsequent phorbol ester-induced edema in rats.
IC 50PKCα: 9.3 nM (IC50); PKC-βI: 28 nM (IC50); PKC-βII: 30 nM (IC50); PKCγ: 36.5 nM (IC50); PKCε: 108.3 nM (IC50); G protein-coupled receptor kinase 5 (GRK5)
storageStore at -20°C
Ro 32-0432 hydrochloride Preparation Products And Raw materials
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