1H-1,2,3-Triazole-4-methanol, 1-(3,4-dichlorophenyl)- manufacturers
- Notum-IN-1
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- $1980.00
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2026-05-11
- CAS:338419-11-7
- Purity:
- Supply Ability: 10g
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| | 1H-1,2,3-Triazole-4-methanol, 1-(3,4-dichlorophenyl)- Basic information |
| | 1H-1,2,3-Triazole-4-methanol, 1-(3,4-dichlorophenyl)- Chemical Properties |
| Melting point | 122-123 °C | | Boiling point | 440.8±55.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | pka | 12.85±0.10(Predicted) |
| | 1H-1,2,3-Triazole-4-methanol, 1-(3,4-dichlorophenyl)- Usage And Synthesis |
| Uses | Notum-IN-1 (compound 6b) is an orally active, selective and brain penetrant inhibitor of Notum. Notum-IN-1 blocks the Wnt signaling in vivo in mouse[1]. | | References | [1] Willis NJ, et al. Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit. J Med Chem. 2022 May 26;65(10):7212-7230. DOI:10.1021/acs.jmedchem.2c00162 |
| | 1H-1,2,3-Triazole-4-methanol, 1-(3,4-dichlorophenyl)- Preparation Products And Raw materials |
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