| Company Name: |
ChemeGen |
| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- manufacturers
- CAY10771
-
- $1560.00
-
2026-04-22
- CAS:2522599-79-5
- Purity:
- Supply Ability: 10g
|
| | Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- Basic information |
| | Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- Chemical Properties |
| Boiling point | 706.8±60.0 °C(Predicted) | | density | 1.368±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Acetonitrile: 5 mg/ml | | pka | 4.57±0.10(Predicted) |
| | Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- Usage And Synthesis |
| Biological Activity | CAY10771 is a dual agonist of farnesoid X receptor (FXR) and peroxisome proliferator-activated receptor δ (PPARδ).1 It activates FXR and PPARδ in reporter assays using HEK293T cells (EC50s = 0.94 and 1.5 μM, respectively) and is selective for these receptors over retinoic acid receptor α (RARα), retinoid X receptor α (RXRα), PPARα, PPARγ, and liver X receptor α (LXRα) at 10 μM. | | References | 1.Schierle, S., Neumann, S., Heitel, P., et al.Design and structural optimization of dual FXR/PPARδ activatorsJ. Med. Chem.63(15)8369-8379(2020) |
| | Benzeneacetic acid, 4-[[[2-chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]- Preparation Products And Raw materials |
|