1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine

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1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine manufacturers
1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Basic information
Product Name:1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine
Synonyms:5-(1,4-diazepane-1-sulfonyl)-1,2-dihydroisoquinolin-1-one;HYDROXYFASUDIL;HA-1100;HA 1100;HA1100;1H-1,4-Diazepine, hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-;Ha 1100;Hexahydro-1-((1,2-dihydro-1-oxo-5-isoquinolinyl)sulfonyl)-1H-1,4-diazepine;1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepinehydrochloride;5-((1,4-diazepan-1-yl)sulfonyl)isoquinolin-1-ol;Fasudil Impurity L
CAS:105628-72-6
MF:C14H17N3O3S
MW:307.37
EINECS:
Product Categories:Angiogenesis and Metastasis;Intracellular signaling
Mol File:105628-72-6.mol
1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Structure
1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Chemical Properties
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility Soluble in DMSO
form Solid
color White to off-white
InChIInChI=1S/C14H17N3O3S/c18-14-12-3-1-4-13(11(12)5-7-16-14)21(19,20)17-9-2-6-15-8-10-17/h1,3-5,7,15H,2,6,8-10H2,(H,16,18)
InChIKeyZAVGJDAFCZAWSZ-UHFFFAOYSA-N
SMILESC1(=O)C2=C(C(S(N3CCCNCC3)(=O)=O)=CC=C2)C=CN1
Safety Information
Toxicitymouse,LD50,unreported,145mg/kg (145mg/kg),United States Patent Document. Vol. #4678783,
MSDS Information
1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Usage And Synthesis
Biological ActivityCell-permeable active metabolite of Fasudil (HA 1077; Fasudil hydrochloride). Produces ATP-competitive and reversible inhibition of Rho-kinase and is ~ 100-fold selective over a range of other protein kinases. Inhibits neutrophil migration and produces potent vasodilatory effects in vivo .
1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Preparation Products And Raw materials
Tag:1-[(1,2-Dihydro-1-oxo-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine(105628-72-6) Related Product Information
5-Quinolinesulfonic acid, 2-methyl- Fasudil Impurity 6 Fasudil Impurity 13 Fasudil Pyridine N-Oxide TFA Salt N-(3-HYDROXYPROPYL)ETHYLENEDIAMINE Fasudil Impurity 9 Fasudil Impurity 34 Fasudil iMpurity Fasudil Impurity 7 1-[(1-Chloro-5-isoquinolinyl)sulfonyl]hexahydro-1H-1,4-diazepine Fasudil Impurity 8 1-Chloro-5-isoquinolinesulfonic Acid Fasudil Impurity 6 1,4-ditosyl-1,4-diazepane Fasudil diMer Fasudil N-hydroxy iMpurity Isoquinoline Hydroxyfasudil monohydrochloride