| Company Name: |
ChemeGen |
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18818260767 |
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2625930290@qq.com |
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| | MMK1 (trifluoroacetate salt) Basic information |
| | MMK1 (trifluoroacetate salt) Chemical Properties |
| solubility | Methanol: soluble |
| | MMK1 (trifluoroacetate salt) Usage And Synthesis |
| Description | MMK1 is an agonist of formyl peptide receptor 2 (FPR2), which was previously known as formyl peptide receptor-like 1 (FPRL1).1 MMK1 induces calcium flux in CHO cells expressing human FPR2 and Gα16 (EC50 = <2 nM) but not in CHO cells expressing Gα16 alone or in combination with FPR1 (EC50s = >10,000 nM for both). It induces chemotaxis of isolated human peripheral blood monocytes and neutrophils in a concentration-dependent manner.2 MMK1 (10 µM) increases production of the proinflammatory cytokines IL-1β and IL-6 in isolated human monocytes. Intracerebroventricular administration of MMK1 (100 pmol/mouse) increases the percentage of time spent in the open arms of the elevated plus maze in mice, indicating anxiolytic-like activity.3WARNING This product is not for human or veterinary use. | | References | [1] CHRISTINE KLEIN. Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeast[J]. Nature biotechnology, 1998, 16 13: 1334-1337. DOI: 10.1038/4310
[2] JIN YUE HU. Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1[J]. Journal of Leukocyte Biology, 2001, 70 1: 155-161. DOI: 10.1189/jlb.70.1.155
[3] HUI ZHAO . Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors[J]. Peptides, 2016, 83: Pages 16-20. DOI: 10.1016/j.peptides.2016.07.001 |
| | MMK1 (trifluoroacetate salt) Preparation Products And Raw materials |
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