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| | 1H-Isoindole-1,3(2H)-dione, 4-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Basic information |
| Product Name: | 1H-Isoindole-1,3(2H)-dione, 4-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) | | Synonyms: | 1H-Isoindole-1,3(2H)-dione, 4-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1);4-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride;1H-Isoindole-1,3(2H)-dione,4-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, monohydrochloride;1H-Isoindole-1,3(2H)-dione, 4-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl) hydrochloride;Thalidomide-CH2NH2 (hydrochloride) | | CAS: | 444287-40-5 | | MF: | C14H14ClN3O4 | | MW: | 323.73 | | EINECS: | | | Product Categories: | | | Mol File: | 444287-40-5.mol |  |
| | 1H-Isoindole-1,3(2H)-dione, 4-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Chemical Properties |
| storage temp. | 2-8°C | | form | powder | | InChI | 1S/C14H13N3O4/c15-6-7-2-1-3-8-11(7)14(21)17(13(8)20)9-4-5-10(18)16-12(9)19/h1-3,9H,4-6,15H2,(H,16,18,19) | | InChIKey | TUMJPYMYNBEMDD-UHFFFAOYSA-N | | SMILES | NCC1=C(C(N(C2CCC(NC2=O)=O)C3=O)=O)C3=CC=C1 |
| WGK Germany | WGK 3 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Repr. 1B |
| | 1H-Isoindole-1,3(2H)-dione, 4-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Usage And Synthesis |
| Uses | 4-Aminomethyl-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione hydrochloride is a functionalized Cereblon ligand used for development of protein degrader building blocks. Contains a terminal amine group, allowing rapid conjugation of carboxyl containing linkers. A basic building block for development of a protein degrader library. | | reaction suitability | reagent type: ligand |
| | 1H-Isoindole-1,3(2H)-dione, 4-(aminomethyl)-2-(2,6-dioxo-3-piperidinyl)-, hydrochloride (1:1) Preparation Products And Raw materials |
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