| Company Name: |
ChemCell Biomedicine Co.,Ltd.
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020-13556033878 2965585218 13556033878 |
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chemcell@hotmail.com |
| Products Intro: |
Product Name:SR18662
CAS:2505001-62-5
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；250mg；500mg；1g；5g；10g；25g；100g
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| | (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide Basic information |
| Product Name: | (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide | | Synonyms: | (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide;(E)3(3,4dichlorophenyl)N(2(4(methylsulfonyl)piperazin1yl)2oxoethyl)acrylamide,(E) 3 (3,4 dichlorophenyl) N (2 (4 (methylsulfonyl)piperazin 1 yl) 2 oxoethyl)acrylamide;2-Propenamide, 3-(3,4-dichlorophenyl)-N-[2-[4-(methylsulfonyl)-1-piperazinyl]-2-oxoethyl]-, (2E)-;SR18662 free base;(E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide, 10 mM in DMSO;(E)-3-(3,4-dichlorophenyl)-N-[2-(4-methylsulfonyl-1-piperazinyl)-2-oxoethyl]-2-propenamide | | CAS: | 2505001-62-5 | | MF: | C16H19Cl2N3O4S | | MW: | 420.31 | | EINECS: | | | Product Categories: | | | Mol File: | 2505001-62-5.mol |  |
| | (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide Chemical Properties |
| density | 1.47±0.1 g/cm3(Predicted) | | pka | 12.97±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide Usage And Synthesis |
| Uses | SR18662 is a potent inhibitor of Krüppel-like factor five (KLF5) with an IC50of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer[1]. | | in vivo | SR18662 (intraperitoneal injection; 5-10 mg/kg; daily or twice daily; 5 days injection, days break, and 5 days) significantly reduces the growth of tumors in a mouse xenograft model[1]. | Animal Model: | Nude mice with DLD-1 cells[1] | | Dosage: | 5 mg/kg; 10 mg/kg; 25 mg/kg | | Administration: | Intraperitoneal injection; 5mg/kg daily, 5mg/kg twice a day,10 mg/kg daily, 10 mg/kg twice per day, 25mg/kg daily, and 25 mg/kg twice per day; 5 days of injections, 2 days break, and 5 days of injections | | Result: | Caused a significant dose-dependent inhibition of xenograft growth in mice. |
| | References | [1] Julie Kim,et al.The Novel Small-Molecule SR18662 Efficiently Inhibits the Growth of Colorectal CancerIn VitroandIn Vivo.Mol Cancer Ther.2019 Nov;18(11):1973-1984. DOI:10.1158/1535-7163.MCT-18-1366 |
| | (E)-3-(3,4-dichlorophenyl)-N-(2-(4-(methylsulfonyl)piperazin-1-yl)-2-oxoethyl)acrylamide Preparation Products And Raw materials |
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