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| | Vocacapsaicin Basic information |
| Product Name: | Vocacapsaicin | | Synonyms: | 1-Piperidinecarboxylic acid, 2-[(methylamino)methyl]-, 2-methoxy-4-[[[(6E)-8-methyl-1-oxo-6-nonen-1-yl]amino]methyl]phenyl ester;Vocacapsaicin;CA-008;2-Methoxy-4-[[[(6E)-8-methyl-1-oxo-6-nonen-1-yl]amino]methyl]phenyl 2-[(methylamino)methyl]-1-piperidinecarboxylate (ACI) | | CAS: | 1931116-86-7 | | MF: | C26H41N3O4 | | MW: | 459.62 | | EINECS: | | | Product Categories: | | | Mol File: | 1931116-86-7.mol |  |
| | Vocacapsaicin Chemical Properties |
| Boiling point | 632.9±55.0 °C(Predicted) | | density | 1.063±0.06 g/cm3(Predicted) | | pka | 15.46±0.46(Predicted) |
| | Vocacapsaicin Usage And Synthesis |
| Description | Vocacapsaicin (CA-008), a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief. | | Uses | Vocacapsaicin (CA-008), a proagent of Capsaicin, is a first-in-class non-opioid TRPV1 agonist. Vocacapsaicin can provide meaningful and long-lasting pain relief[1]. | | Mode of action | Vocacapsaicin(CA-008, Conentric Analgesics) – an investigational TRPV agonist being studied for long-lasting pain – works through the same TRPV1 agonism mechanism but its localized delivery is thought to minimize activation of a large array of neurons, such as capsaicin topical products. | | References | [1] TARRA KNOTTS. Pharmacokinetics and local tissue response to local instillation of vocacapsaicin, a novel capsaicin prodrug, in rat and rabbit osteotomy models[J]. Journal of Orthopaedic Research, 2022, 40 10: 2281-2293. DOI:10.1002/jor.25271.
[2]. Olivia Higgins, et al. Analgesics of the Future: The Potential of Vocacapsaicin Injections for Knee Pain. 12 Articles in Volume 21, Issue #2. |
| | Vocacapsaicin Preparation Products And Raw materials |
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