(D-TRP11)-NEUROTENSIN
| 中文名称 | (D-TRP11)-NEUROTENSIN |
|---|---|
| 中文同义词 | 神经降压肽[DTRP11]NEUROTENSIN;D-色氨酸11]神经降压素 |
| 英文名称 | Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH |
| 英文同义词 | PYR-LYENKPRRPWIL;PYR-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-D-TRP-ILE-LEU;[D-TRP11]-NEUROTENSIN;GLP-LEU-TYR-GLU-ASN-LYS-PRO-ARG-ARG-PRO-DTRP-ILE-LEU;pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu;pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH;Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-D-Trp-Ile-Leu-OH |
| CAS号 | 73634-68-1 |
| 分子式 | C80H122N22O19 |
| 分子量 | 1695.96 |
| EINECS号 | |
| 相关类别 | 多肽;Peptide |
| Mol文件 | Mol File |
| 结构式 |  |
(D-TRP11)-NEUROTENSIN 性质
| 储存条件 | -15°C |
|---|---|
| 序列 | {Pyr}-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-{D-Trp}-Ile-Leu |
[D-Trp11]-Neurotensin 是 Neurotensin (NT) 的类似物，在灌注的大鼠心脏中是 NT 的选择性拮抗剂，但在豚鼠心房和大鼠胃条中起完全激动剂的作用。[D-Trp11]-Neurotensin 可抑制 NT 引起的低血压。
Neurotensin Receptor
[D-Trp11]-Neurotensin (0.13-1.1 μM) markedly inhibits NT-induced coronary vessel constriction in perfused rat hearts.
[D-Trp11]-Neurotensin (2-110 μM) exhibits NT-like activity in perfused rat hearts.
[D-Trp11]-Neurotensin (50-500 nmol/kg; i.v.) has hypotensive activity in pentobarbital-anesthetized rats, with an ED 25 of 122 nmol/kg.