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EFIPLADIB

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EFIPLADIB Suppliers list
Company Name: Tianjin Anhao Biological Technology Co., Ltd.  
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Email: sales@ahpharmatech.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: Nanjing Shizhou Biology Technology Co.,Ltd  
Tel: 025-85560043 15850508050
Email: cindy.huang@synzest.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

EFIPLADIB manufacturers

  • Efipladib
  • Efipladib pictures
  • $2380.00
  • 2026-05-21
  • CAS:381683-94-9
  • Purity:
  • Supply Ability: 10g
EFIPLADIB Basic information
Product Name:EFIPLADIB
Synonyms:EFIPLADIB;4-(3-(5-chloro-2-(2-(((3,4-dichlorobenzyl)sulfonyl)aMino)ethyl)-1-(diphenylMethyl)-1H-indol-3-yl)propyl)benzoic acid;4-(3-(1-benzhydryl-5-chloro-2-(2-((3,4-dichlorophenyl)MethylsulfonaMido)ethyl)-1H-indol-3-yl)propyl)benzoic acid;Efipladib (PLA 902);Benzoic acid, 4-[3-[5-chloro-2-[2-[[[(3,4-dichlorophenyl)methyl]sulfonyl]amino]ethyl]-1-(diphenylmethyl)-1H-indol-3-yl]propyl]-;PLA 902;PLA902;PLA-902
CAS:381683-94-9
MF:C40H35Cl3N2O4S
MW:746.14
EINECS:
Product Categories:
Mol File:381683-94-9.mol
EFIPLADIB Structure
EFIPLADIB Chemical Properties
Melting point 172 °C
Boiling point 891.2±75.0 °C(Predicted)
density 1.32±0.1 g/cm3(Predicted)
pka4.34±0.10(Predicted)
Safety Information
MSDS Information
EFIPLADIB Usage And Synthesis
UsesTreatment of pain and symptomatic management of arthritis.
in vivo

Efipladib (100 mg/kg; p.o.; BID for 31 days) reverses the severity in mouse collagen-induced arthritis (CIA) model[1].
Efipladib (100 mg/kg; p.o.; once) significantly inhibits the nociceptive response 1 h after administration in the rat Complete Freund’s Adjuvant (CFA) nociception model[2].
Efipladib is unable to cross the BBB to gain access to the central compartment[2].
Efipladib (100 nM; IT; 5 μL) reduces PGE2 levels in the cerebrospinal fluid in rats[2].

Animal Model:Mouse collagen-induced arthritis (CIA) model[1]
Dosage:100 mg/kg
Administration:PO, BID for 31 days
Result:Gave a dramatic reduction in the clinical disease severity score relative to the vehicle treated group.
Animal Model:Male Sprague-Dawley rats[2]
Dosage:100 nM in 5 μL of 100% DMSO/rat
Administration:Intrathecal administration
Result:Reduced PGE2 levels in the cerebrospinal fluid (CSF) by 45-60%, yet there was no effect on the nociceptive response.
IC 50cPLA2α: 0.04 μM (IC50); cPLA2α: 0.067 μM (Ki)
EFIPLADIB Preparation Products And Raw materials
Tag:EFIPLADIB(381683-94-9) Related Product Information
ECOPLADIBUM GIRIPLADIB EFIPLADIB Benzoic acid, 4-[[6-chloro-1-(diphenylmethyl)-1H-indol-3-yl]methyl]-3-methoxy- Neomycin sulfate MANUMYCIN A