| Company Name: |
LGM Pharma |
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
EPLIVANSERIN FUMARATE manufacturers
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| | EPLIVANSERIN FUMARATE Basic information |
| Product Name: | EPLIVANSERIN FUMARATE | | Synonyms: | EPLIVANSERIN FUMARATE;SR 46349B;TRANS-2''-FLUORO-4-HYDROXYCHALCONE O-[(Z)-2-(DIMETHYLAMINO)ETHYL]OXIME--FUMARIC ACID (2:1);(Z,E)-1-(2-Fluorophenyl)-3-(4-hydroxyphenyl)-2-propen-1-one O-[2-(dimethylamino)ethyl]oxime fumarate (2:1);Eplivanserin hemifumarate;4-((3Z)-3-(2-Dimethylaminoethyl)oxyimino-3-(2-fluorophenyl)propen-1-yl)phenol hemifumarate salt;Eplivanserin hemifumarate salt;SR-46349 hemifumarate salt | | CAS: | 130580-02-8 | | MF: | C23H25FN2O6 | | MW: | 444.46 | | EINECS: | | | Product Categories: | | | Mol File: | 130580-02-8.mol |  |
| | EPLIVANSERIN FUMARATE Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: ≥10mg/mL | | form | powder | | color | white to off-white | | InChIKey | RNLKLYQQDLHHBH-ABDBJYMXSA-N | | SMILES | OC(=O)\C=C\C(O)=O.CN(C)CCO\N=C(\C=C\c1ccc(O)cc1)c2ccccc2F.CN(C)CCO\N=C(\C=C\c3ccc(O)cc3)c4ccccc4F |
| Hazard Codes | Xn,N | | Risk Statements | 22-50 | | Safety Statements | 61 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 2 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Acute 1
Aquatic Chronic 1 |
| | EPLIVANSERIN FUMARATE Usage And Synthesis |
| Uses | Eplivanserin Hemifumarate is a 5-HT2A antagonist. | | Biological Activity | SR-46349 is an antagonist of 5-HT (2A/2C) receptor and increases the release of dopamine by medial prefrontal cortex in rats.1 It increases the signal transduction induced by 5-HT2 receptor by binding with high affinity.2 SR-46349 inhibits the aggregation of rabbit and human platelets in response to serotonin.3', 'ASTAR (Antagonist of Serotonin 5HT2A Receptors). | | in vivo | Eplivanserin hemifumarate (SR 46349B) inhibits 5-HT2 receptor binding of [3H]ketanserin with an ED50 of 0.087 mg/kg after i.p. injection, and 0.097 mg/kg after p.o administration in mice[1].
SR 46349B (0.25-1 mg/kg; i.p.) blocks Cocaine-evoked hyperactivity following repeated Cocaine treatment in rats[2]. | | IC 50 | 5-HT2A Receptor: 5.8 nM (IC50); 5-HT2C Receptor: 120 nM (IC50) | | storage | Store at +4°C |
| | EPLIVANSERIN FUMARATE Preparation Products And Raw materials |
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