| Company Name: |
TCI Europe |
| Tel: |
320-37350700 |
| Email: |
sales@tcieurope.eu |
| Company Name: |
TCI AMERICA |
| Tel: |
800-4238616 |
| Email: |
sales@tciamerica.com |
MELPERONE manufacturers
- Melperone
-
- $40.00
-
2026-06-02
- CAS:3575-80-2
- Purity: 98.84%
- Supply Ability: 10g
- Melperone
-
- $1.00
-
2024-07-20
- CAS:3575-80-2
- Min. Order: 1Kg
- Purity: 98%
- Supply Ability: 20T
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| | MELPERONE Basic information |
| Product Name: | MELPERONE | | Synonyms: | metylperon;Melperone (base and/or unspecified salts);1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)-1-butanone;Melperon;1-(4-Fluorophenyl)-4-(4-methylpiperidin-1-yl)butan-1-one;1-(4-Fluorophenyl)-4-(4-Methyl-1-piperidinyl)-1-butanone;4'-Fluoro-4-(4-Methylpiperidino)butyrophenone;4-Fluoro-γ-(4-Methylpiperidino)butyrophenone | | CAS: | 3575-80-2 | | MF: | C16H22FNO | | MW: | 263.35 | | EINECS: | 609-173-2 | | Product Categories: | | | Mol File: | 3575-80-2.mol |  |
| | MELPERONE Chemical Properties |
| Melting point | 78.0 to 82.0 °C | | Boiling point | bp0.1 120-125° | | density | 1.046±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 41.67 mg/mL (158.23 mM) | | form | powder to crystal | | pka | 9.34±0.10(Predicted) | | color | White to Light yellow to Light orange | | Merck | 14,5827 |
| | MELPERONE Usage And Synthesis |
| Originator | Eunerpan,Nordmark,W. Germany,1965 | | Definition | ChEBI: 1-(4-fluorophenyl)-4-(4-methyl-1-piperidinyl)-1-butanone is an aromatic ketone. | | Manufacturing Process | A solution or dispersion consisting of 20.1 g (0.1 mol) of γ-chloro-pfluorobutyrophenone, 19.8 g (0.2 mol) of 4-methylpiperidine and 0.1 g of potassium iodide in 150 ml toluene is heated in a sealed glass tube for 15 hours at 100°C to 110°C. The potassium iodide and the 4-methylpiperidine hydrochloride formed in the reaction are separated by filtration and the solvent removed from the filtrate by evaporation in vacuum on a steam bath. The residue is distilled and the fraction obtained at 120°C to 125°C and at a pressure lower than 0.1 mm Hg is collected. The base is dissolved in ether and the 4-fluoro-γ-(4-methylpiperidino)-butyrophenone precipitated as the hydrochloride. The reaction product is purified by recrystallization in ethanol/ether.
Yield 22.0 g (73% of theory). MP 209°C to 211°C. | | Therapeutic Function | Neuroleptic |
| | MELPERONE Preparation Products And Raw materials |
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