2-METHYL[1,3]OXAZOLO[4,5-B]PYRIDINE manufacturers
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| | 2-METHYL[1,3]OXAZOLO[4,5-B]PYRIDINE Basic information |
| | 2-METHYL[1,3]OXAZOLO[4,5-B]PYRIDINE Chemical Properties |
| Melting point | 74 °C(Solv: ligroine (8032-32-4)) | | Boiling point | 214.3±13.0 °C(Predicted) | | density | 1.229±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | form | solid | | pka | 0.22±0.50(Predicted) | | color | Yellow |
| | 2-METHYL[1,3]OXAZOLO[4,5-B]PYRIDINE Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-methyloxazolo[4,5-B]pyridine from 2-amino-3-hydroxypyridine and triethyl orthoacetate: 80 mL of triethyl orthoacetate was added to 15 g (136 mmol) of 2-amino-3-hydroxypyridine, followed by the addition of a catalytic amount of p-toluenesulfonic acid. The reaction mixture was stirred at 120 °C for 4 hours. After completion of the reaction, the reaction mixture was cooled and triethylamine was added to neutralize p-toluenesulfonic acid in the reaction system. Subsequently, the solvent was removed by distillation under reduced pressure using a rotary evaporator. The crude product was purified by silica gel column chromatography to afford 12.0 g of the target product 2-methyloxazolo[4,5-B]pyridine in 65.8% yield. | | References | [1] Monatshefte fur Chemie, 2011, vol. 142, # 1, p. 87 - 91
[2] Heterocycles, 1995, vol. 41, # 3, p. 477 - 486
[3] Monatshefte fur Chemie, 2007, vol. 138, # 7, p. 663 - 667
[4] Patent: US2009/247736, 2009, A1. Location in patent: Page/Page column 13
[5] Tetrahedron Letters, 1990, vol. 31, # 8, p. 1155 - 1156 |
| | 2-METHYL[1,3]OXAZOLO[4,5-B]PYRIDINE Preparation Products And Raw materials |
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