- ACTH (1-39), rat
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2026-08-25
- CAS:77465-10-2
- Min. Order: 1kg
- Purity: >99%
- Supply Ability: 20 tons
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| | ADRENOCORTICOTROPIC HORMONE RAT Basic information |
| Product Name: | ADRENOCORTICOTROPIC HORMONE RAT | | Synonyms: | ACTH 1-39;ACTH (1-39) (MOUSE, RAT);ACTH (1-39) (RAT);ADRENOCORTICOTROPIC HORMONE RAT;ADRENOCORTICOTROPIC HORMONE (1-39) (RAT);CORTICOTROPIN A;H-SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-VAL-ALA-GLU-ASN-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE-OH;SER-TYR-SER-MET-GLU-HIS-PHE-ARG-TRP-GLY-LYS-PRO-VAL-GLY-LYS-LYS-ARG-ARG-PRO-VAL-LYS-VAL-TYR-PRO-ASN-VAL-ALA-GLU-ASN-GLU-SER-ALA-GLU-ALA-PHE-PRO-LEU-GLU-PHE | | CAS: | 77465-10-2 | | MF: | C210H315N57O57S1 | | MW: | 4582.16 | | EINECS: | | | Product Categories: | Peptide | | Mol File: | Mol File | ![ADRENOCORTICOTROPIC HORMONE RAT Structure]() |
| | ADRENOCORTICOTROPIC HORMONE RAT Chemical Properties |
| storage temp. | −20°C | | solubility | Soluble in DMSO | | form | Solid | | color | White to off-white | | Sequence | H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Val-Ala-Glu-Asn-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH |
| | ADRENOCORTICOTROPIC HORMONE RAT Usage And Synthesis |
| Uses | Adrenocorticotropic Hormone (ACTH) (1-39), rat is a potent melanocortin 2 (MC2) receptor agonist. | | in vivo | The icv injection of ACTH significantly reduces cumulative food intake over the observation period compared with the saline/IgG group. The injection of ACTH Ab into the PVN abolishes the anorexigenic effect of ACTH. Infusion icv of ACTH significantly decreases cumulative food intake in rats that receive α-MSH Ab into the PVN and ACTH icv, and food intake is as low as in the group treated with ACTH icv and IgG into the PVN. Injection of either ACTH Ab or α-MSH Ab into the PVN significantly increase cumulative food intake compared with IgG-treated animals; the combined application of both Ab’s do not increase food intake further[2]. | | References | [1] Lisak RP, et al. Melanocortin receptor agonist ACTH 1-39 protects rat forebrain neurons from apoptotic, excitotoxic and inflammation-related damage. Exp Neurol. 2015 Nov;273:161-7. DOI:10.1016/j.expneurol.2015.08.012
[2] Schulz C, et al. Endogenous ACTH, not only alpha-melanocyte-stimulating hormone, reduces food intake mediated by hypothalamic mechanisms. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E237-44. DOI:10.1152/ajpendo.00408.2009 |
| | ADRENOCORTICOTROPIC HORMONE RAT Preparation Products And Raw materials |
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